Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL632045 | 0.87 | ALDH1A1 (0.67) | MAPTALDH1A1HPGDRAB9ANPC1 | |
| Terephthalamide SCHEMBL30182529 | 0.84 | PARP1 (0.56) | MAPTALDH1A1HSD17B10KMT2APOLB | |
| SCHEMBL5949981 | 0.77 | MAPT (0.59) | MAPTALDH1A1HPGDRAB9ANPC1 | |
| Trifluoroacetic Acid SCHEMBL27505171 | 0.77 | HDAC4 (0.51) | MAPTALDH1A1HPGDKMT2AMEN1 | |
| Benzamide SCHEMBL9005948 | 0.77 | PARP1 (0.73) | MAPTALDH1A1HSD17B10POLBL3MBTL1 | |
| Benzamide SCHEMBL29494570 | 0.77 | PARP1 (0.73) | MAPTALDH1A1HSD17B10POLBL3MBTL1 | |
| Benzamide SCHEMBL1786300 | 0.77 | PARP1 (0.73) | MAPTALDH1A1HSD17B10POLBL3MBTL1 | |
| SCHEMBL6712807 | 0.76 | NPC1 (0.71) | MAPTALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL6712805 | 0.76 | NPC1 (0.71) | MAPTALDH1A1HPGDRAB9ANPC1 | |
| Trifluoroacetic Acid SCHEMBL8845055 | 0.76 | TPMT (0.50) | MAPTALDH1A1HSD17B10KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042287-B1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | AVENTIS PHARMA GMBH (DE) | 2005-04-20 | — | — | EP | disclosed |
| US-6337344-B1 | ANTICOAGULANTS AND ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-01-08 | — | — | US | disclosed |
| EP-1042287-A1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | Aventis Pharma Deutschland GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033800-A1 | INDOLE DERIVATIVES AS INHIBITORS OR FACTOR XA | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-08 | — | — | WO | disclosed |