SCHEMBL6436895

SCHEMBL6436895

CC12COC(CCc3ccc(Br)cc3)(OC1)OC2

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 4/20 0.39
HMOX1 P09601 2/20 0.39
HTR2A P28223 1/20 0.38
OPRM1 P35372 2/20 0.35
OPRD1 P41143 2/20 0.35
OPRK1 P41145 2/20 0.35
OPRL1 P41146 1/20 0.35
KDM1A O60341 1/20 0.34
RCOR1 Q9UKL0 1/20 0.34
CXCR3 P49682 1/20 0.33
SIGMAR1 Q99720 1/20 0.33
POLB P06746 1/20 0.32
CTDSP1 Q9GZU7 1/20 0.32
FPR2 P25090 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13535442 0.83 HMOX1 (0.37) TAAR1HMOX1HTR2AOPRM1OPRD1
SCHEMBL21509221 0.80 TAAR1 (0.42) TAAR1HMOX1HTR2AOPRM1OPRD1
SCHEMBL1376365 0.76 TAAR1 (0.45) TAAR1HMOX1HTR2AOPRM1OPRD1
SCHEMBL6441253 0.76 MAOB (0.41)
SCHEMBL12126621 0.75 HMOX1 (0.47) TAAR1HMOX1HTR2AOPRM1OPRD1
SCHEMBL932856 0.75 HMOX1 (0.38) TAAR1HMOX1HTR2AOPRM1OPRD1
SCHEMBL6441762 0.74 DRD4 (0.41)
SCHEMBL6440105 0.71 EPHX2 (0.33)
SCHEMBL12144581 0.70 KDM1A (0.48) TAAR1HMOX1HTR2AOPRM1OPRD1
SCHEMBL18722019 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1506959-A2 Derivatised molecules for mass spectrometry OXFORD GENE TECHNOLOGY IP LIMITED (GB) 2005-02-16 EP disclosed