Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 9/20 | 0.69 |
| ▸ | CCR2 | P41597 | 6/20 | 0.62 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.52 |
| ▸ | KLK1 | P06870 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6432496 | 0.93 | F10 (0.62) | F10CCR2KLKB1KLK1CNR1 | |
| SCHEMBL6436698 | 0.93 | F10 (0.66) | F10CCR2KLKB1KLK1CNR1 | |
| SCHEMBL6432441 | 0.88 | F10 (0.58) | F10CCR2KLKB1KLK1CNR1 | |
| SCHEMBL6432777 | 0.88 | F10 (0.57) | F10CCR2KLKB1KLK1PPARG | |
| SCHEMBL6432780 | 0.88 | F10 (0.56) | F10CCR2KLKB1KLK1CNR1 | |
| SCHEMBL13900117 | 0.82 | F10 (0.68) | F10CCR2PPARGF2TP53 | |
| SCHEMBL7712483 | 0.82 | F10 (0.53) | F10CCR2KLKB1KLK1PPARG | |
| SCHEMBL12585719 | 0.81 | F10 (0.70) | F10CCR2TP53 | |
| SCHEMBL6434179 | 0.81 | F10 (0.51) | F10CCR2KLKB1KLK1PPARG | |
| SCHEMBL6433076 | 0.80 | CCR2 (0.77) | F10CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042287-B1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | AVENTIS PHARMA GMBH (DE) | 2005-04-20 | — | — | EP | disclosed |
| US-6337344-B1 | ANTICOAGULANTS AND ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-01-08 | — | — | US | disclosed |
| EP-1042287-A1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | Aventis Pharma Deutschland GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033800-A1 | INDOLE DERIVATIVES AS INHIBITORS OR FACTOR XA | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-08 | — | — | WO | disclosed |