Sugi Predict

Sugi Predict / Compounds / SCHEMBL6437555

SCHEMBL6437555

SCHEMBL6437555

CC(C)(C)OC(=O)CN(Cc1ccncc1)S(=O)(=O)c1ccc2c(Cl)cnc(NC(=N)N)c2c1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ PLAU P00749 9/20 0.47
▸ MMP1 P03956 4/20 0.38
▸ MMP2 P08253 4/20 0.38
▸ MMP9 P14780 4/20 0.38
▸ MMP8 P22894 4/20 0.38
▸ MMP13 P45452 4/20 0.38
▸ PLG P00747 2/20 0.37
▸ PLAT P00750 1/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ KDM4E B2RXH2 1/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ PKM P14618 1/20 0.35
▸ HTT P42858 1/20 0.35
▸ RECQL P46063 1/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ NR1D1 P20393 1/20 0.35
▸ MAPT P10636 1/20 0.34
▸ PTGER2 P43116 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6432627 0.93 PLAU (0.56) PLAUMMP1MMP2MMP9MMP8
SCHEMBL6434978 0.92 PLAU (0.47) PLAUMMP1MMP2MMP9MMP8
SCHEMBL6434470 0.91 PLAU (0.44) PLAUPLGPLATALDH1A1NR1D1
SCHEMBL6437213 0.91 PLAU (0.46) PLAUMMP1MMP2MMP9MMP8
Hydrochloric Acid SCHEMBL6438528 0.90 PLAU (0.46) PLAUMMP1MMP2MMP9MMP8
SCHEMBL6434142 0.89 PLAU (0.50) PLAUMMP1MMP2MMP9MMP8
Hydrochloric Acid SCHEMBL6434136 0.88 PLAU (0.49) PLAUMMP1MMP2MMP9MMP8
SCHEMBL6438996 0.88 PLAU (0.46) PLAUPLGPLATALDH1A1SMN1; SMN2
SCHEMBL6437200 0.87 PLAU (0.46) PLAUMMP1MMP2MMP9MMP8
Hydrochloric Acid SCHEMBL6434573 0.87 PLAU (0.60) PLAUMMP1MMP2MMP9MMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050026836-A1 Composition for the treatment of damaged tissue DACK KEVIN NEIL (GB) 2005-02-03 — — US disclosed
US-20030199440-A1 Composition for the treatment of damaged tissue PFIZER INC. 2003-10-23 — — US disclosed
EP-1077945-B1 ISOQUINOLINES AS UROKINASE INHIBITORS PFIZER (US) 2003-01-08 — — EP disclosed
EP-1242120-A2 COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE Pfizer Limited (GB) 2002-09-25 — — EP disclosed
WO-2001049309-A2 COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE PFIZER LIMITED (GB) 2001-07-12 — — WO disclosed
EP-1077945-A1 ISOQUINOLINES AS UROKINASE INHIBITORS PFIZER INC. (US) 2001-02-28 — — EP disclosed
US-6093731-A Isoquinolines PFIZER INC. 2000-07-25 — — US disclosed
WO-2000005214-A2 ISOQUINOLINES AS UROKINASE INHIBITORS PFIZER INC. (US) 2000-02-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030199440-A1 Composition for the treatment of damaged tissue MMP1, SERPINE1, COL14A1 PLAU 119/4885MMP1 1/4885MMP2 19/4885
US-20050026836-A1 Composition for the treatment of damaged tissue MMP1, SERPINE1, COL14A1 PLAU 119/4885MMP1 1/4885MMP2 19/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.