Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | HPGD | P15428 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 4/20 | 0.48 |
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3914875 | 0.92 | ALDH1A1 (0.69) | MAPTHPGDALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL6435364 | 0.80 | KMT2A (0.85) | MAPTHPGDALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL3924730 | 0.78 | ALDH1A1 (0.82) | MAPTHPGDALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL3280415 | 0.76 | POLB (0.61) | MAPTHPGDALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL8290736 | 0.76 | ALDH1A1 (0.61) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL3911839 | 0.75 | ALDH1A1 (0.77) | MAPTHPGDALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL3914675 | 0.75 | ALDH1A1 (0.67) | MAPTHPGDALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL3916269 | 0.74 | CYP1A2 (0.77) | MAPTHPGDALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL3914077 | 0.74 | ALDH1A1 (0.77) | MAPTHPGDALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL3279858 | 0.73 | ALDH1A1 (0.73) | MAPTHPGDALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492783-A1 | 4,5,6,7-TRETRAHYDROBENZO(B) THIOPHENE DERIVATIVES AND METHODS FOR MEDICAL INTERVENTION AGAINST MYCROBACTERIAL INFECTIONS | Axxima Pharmaceuticals AG (DE) | 2005-01-05 | — | — | EP | claimed |
| WO-2003084947-A1 | 4,5,6,7-TRETRAHYDROBENZO[B] THIOPHENE DERIVATIVES AND METHODS FOR MEDICAL INTERVENTION AGAINST MYCROBACTERIAL INFECTIONS | AXXIMA PHARMACEUTICALS AG (DE) | 2003-10-16 | — | — | WO | claimed |