Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.42 |
| ▸ | NEK4 | P51957 | 1/20 | 0.42 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.42 |
| ▸ | STK3 | Q13188 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6439157 | 0.86 | ITGB3 (0.40) | AURKAAURKBPLK4ROCK2MAP4K4 | |
| SCHEMBL5029799 | 0.81 | ITGB3 (0.65) | ITGB3ITGAVPDE10A | |
| SCHEMBL5025678 | 0.78 | ITGB3 (0.47) | AURKAAURKBPLK4ROCK2MAP4K4 | |
| SCHEMBL6439741 | 0.77 | ITGB3 (0.46) | AURKAAURKBPLK4ROCK2MAP4K4 | |
| SCHEMBL6439441 | 0.76 | ITGB3 (0.51) | AURKAAURKBPLK4ROCK2MAP4K4 | |
| SCHEMBL6439267 | 0.75 | AURKA (0.37) | AURKAAURKBPLK4ROCK2MAP4K4 | |
| SCHEMBL6426183 | 0.73 | ITGB3 (0.51) | GSK3AGSK3BITGB3ITGAV | |
| SCHEMBL6440629 | 0.67 | ITGB3 (0.56) | ITGB3ITGAVHSD17B10 | |
| SCHEMBL6439935 | 0.66 | ITGB3 (0.50) | ITGB3ITGAVHSD17B10 | |
| SCHEMBL6445902 | 0.65 | ITGB3 (0.59) | ITGB3ITGAVMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1286673-B8 | LIGANDS OF INTEGRIN RECEPTORS | ABBOTT GMBH & CO KG (DE) | 2005-07-20 | — | — | EP | disclosed |
| EP-1286673-A2 | LIGANDS OF INTEGRIN RECEPTORS | Basf Aktiengesellschaft (DE) | 2003-03-05 | — | — | EP | disclosed |
| WO-2001093840-A2 | LIGANDS OF INTEGRIN RECEPTORS | BASF AG (DE) | 2001-12-13 | — | — | WO | disclosed |