Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6436174 | 0.89 | MAPT (0.58) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6434559 | 0.85 | MAPT (0.51) | KDM4EMAPTKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6435204 | 0.85 | MAPT (0.55) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6436649 | 0.81 | MAPT (0.53) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6436995 | 0.79 | KDM4E (0.51) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6439565 | 0.75 | CYP1A1 (0.56) | KDM4EMAPTSMN1; SMN2ALDH1A1PTGDR2 | |
| SCHEMBL11460695 | 0.74 | KDM4E (0.58) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11284205 | 0.74 | KDM4E (0.58) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11462189 | 0.74 | KDM4E (0.58) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14148558 | 0.73 | KDM4E (0.72) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492778-A1 | (4,2-DISUBSTITUTED-THIAZOL-5-YL)AMINE COMPOUNDS AS PDE7 INHIBITORS | Warner-Lambert Company LLC (US) | 2005-01-05 | — | — | EP | claimed |
| US-6753340-B2 | AUTOIMMUNE DISEASE, ANTIARTHRITIC AGENTS, ANTIALLERGENS, ANTICANCER AGENTS | WARNER-LAMBERT COMPANY LLC | 2004-06-22 | — | — | US | claimed |
| US-20030191167-A1 | (4,2-Disubstituted-thiazol-5-yl)amine compounds as PDE7 inhibitors | WARNER-LAMBERT COMPANY LLC | 2003-10-09 | — | — | US | claimed |
| WO-2003082839-A1 | (4,2-DISUBSTITUTED-THIAZOL-5-YL)AMINE COMPOUNDS AS PDE7 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2003-10-09 | — | — | WO | claimed |
| EP-1492778-A1 | (4,2-DISUBSTITUTED-THIAZOL-5-YL)AMINE COMPOUNDS AS PDE7 INHIBITORS | Warner-Lambert Company LLC (US) | 2005-01-05 | — | — | EP | disclosed |
| US-6753340-B2 | AUTOIMMUNE DISEASE, ANTIARTHRITIC AGENTS, ANTIALLERGENS, ANTICANCER AGENTS | WARNER-LAMBERT COMPANY LLC | 2004-06-22 | — | — | US | disclosed |
| US-20030191167-A1 | (4,2-Disubstituted-thiazol-5-yl)amine compounds as PDE7 inhibitors | WARNER-LAMBERT COMPANY LLC | 2003-10-09 | — | — | US | disclosed |
| WO-2003082839-A1 | (4,2-DISUBSTITUTED-THIAZOL-5-YL)AMINE COMPOUNDS AS PDE7 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030191167-A1 | (4,2-Disubstituted-thiazol-5-yl)amine compounds as PDE7 inhibitors | PDE7A, PDE9A, PDE3A | KDM4E 2519/4885MAPT 2707/4885MEN1 2059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.