Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.70 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20909473 | 0.88 | SMPD1 (0.81) | BRD4SMPD1HDAC1HDAC8HDAC6 | |
| SCHEMBL24077087 | 0.88 | SMPD1 (0.72) | BRD4SMPD1HDAC1HDAC8HDAC6 | |
| SCHEMBL8512056 | 0.85 | BRD4 (0.64) | BRD4SMPD1HDAC1HDAC8HDAC6 | |
| SCHEMBL8538875 | 0.80 | BRD4 (0.58) | BRD4SMPD1HDAC1HDAC8HDAC6 | |
| SCHEMBL20626053 | 0.80 | BRD4 (0.54) | BRD4SMPD1HDAC1HDAC8HDAC6 | |
| SCHEMBL3245222 | 0.79 | SMPD1 (0.67) | SMPD1HDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL3123036 | 0.79 | MAOB (0.64) | BRD4SMPD1HDAC1HDAC8HDAC6 | |
| SCHEMBL16004812 | 0.79 | MEN1 (0.64) | BRD4SMPD1HDAC1HDAC8HDAC6 | |
| SCHEMBL1600077 | 0.78 | MRGPRX4 (0.62) | SMPD1HDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL29556736 | 0.78 | MRGPRX4 (0.62) | SMPD1HDAC1HDAC8HDAC6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499577-A1 | 2-(2,6-DICHLOROPHENYL)-DIARYLIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003087026-A1 | 2-(2,6-DICHLOROPHENYL)-DIARYLIMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-23 | — | — | WO | disclosed |