Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 5/20 | 0.81 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.81 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.81 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.81 |
| ▸ | BRD4 | O60885 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | RXRA | P19793 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24077087 | 0.95 | SMPD1 (0.72) | SMPD1HDAC1HDAC8HDAC6BRD4 | |
| SCHEMBL28591307 | 0.89 | SMPD1 (1.00) | SMPD1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL6584177 | 0.89 | SMPD1 (0.81) | SMPD1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL6440137 | 0.88 | BRD4 (0.70) | SMPD1HDAC1HDAC8HDAC6BRD4 | |
| SCHEMBL2188210 | 0.86 | SMPD1 (0.76) | SMPD1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL1029034 | 0.86 | SMPD1 (0.75) | SMPD1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL29375753 | 0.86 | SMPD1 (0.75) | SMPD1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL28033750 | 0.85 | SMPD1 (0.73) | SMPD1HDAC1HDAC8HDAC6BRD4 | |
| SCHEMBL11271923 | 0.85 | SMPD1 (0.73) | SMPD1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL9236564 | 0.85 | SMPD1 (0.73) | SMPD1HDAC1HDAC8HDAC6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190111044-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | Prosetta Antiviral, Inc. | 2019-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190111044-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | MAVS, EIF2AK2, POLRMT | SMPD1 1907/4885HDAC1 960/4885HDAC8 1976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.