Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2740861 | 0.80 | EPHX1 (0.55) | EPHX1SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL3915783 | 0.77 | EPHX1 (0.50) | EPHX1SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL2233593 | 0.76 | EPHX1 (0.50) | EPHX1SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL8345551 | 0.76 | EPHX1 (0.50) | EPHX1SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL1854094 | 0.76 | ALDH1A1 (0.64) | EPHX1SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL23736061 | 0.76 | EPHX1 (0.50) | EPHX1SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL530140 | 0.76 | EPHX1 (0.64) | EPHX1SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL19359635 | 0.76 | EPHX1 (0.50) | EPHX1SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL19359634 | 0.76 | EPHX1 (0.50) | EPHX1SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL3070836 | 0.76 | EPHX1 (0.50) | EPHX1SMN1; SMN2ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936622-B2 | 6-phenylbenzonaphthyridines | ALTANA PHARMA AG (DE) | 2005-08-30 | — | — | US | claimed |
| EP-1377574-B1 | 6-PHENYLBENZONAPHTHYRIDINES | BYK GULDEN LOMBERG CHEM FAB (DE) | 2005-01-19 | — | — | EP | claimed |
| US-20040097537-A1 | 6-phenylbenzonaphthyridines | TAKEDA GMBH (DE) | 2004-05-20 | — | — | US | claimed |
| EP-1377574-A1 | 6-PHENYLBENZONAPHTHYRIDINES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2004-01-07 | — | — | EP | claimed |
| WO-2002066476-A9 | 6-PHENYLBENZONAPHTHYRIDINES | ALTANA PHARMA AG (DE) | 2003-10-30 | — | — | WO | claimed |
| WO-2002066476-A1 | 6-PHENYLBENZONAPHTHYRIDINES | ALTANA PHARMA AG (DE) | 2002-08-29 | — | — | WO | claimed |
| US-6936622-B2 | 6-phenylbenzonaphthyridines | ALTANA PHARMA AG (DE) | 2005-08-30 | — | — | US | disclosed |
| EP-1377574-B1 | 6-PHENYLBENZONAPHTHYRIDINES | BYK GULDEN LOMBERG CHEM FAB (DE) | 2005-01-19 | — | — | EP | disclosed |
| US-20040097537-A1 | 6-phenylbenzonaphthyridines | TAKEDA GMBH (DE) | 2004-05-20 | — | — | US | disclosed |
| EP-1377574-A1 | 6-PHENYLBENZONAPHTHYRIDINES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002066476-A9 | 6-PHENYLBENZONAPHTHYRIDINES | ALTANA PHARMA AG (DE) | 2003-10-30 | — | — | WO | disclosed |
| WO-2002066476-A1 | 6-PHENYLBENZONAPHTHYRIDINES | ALTANA PHARMA AG (DE) | 2002-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097537-A1 | 6-phenylbenzonaphthyridines | PDE3A, PDE4A, PDE3B | EPHX1 2106/4885SMN1; SMN2 3290/4885ALDH1A1 879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.