⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10455578 | 0.92 | — | — | |
| SCHEMBL5842289 | 0.90 | EPHX1 (0.56) | — | |
| SCHEMBL4755259 | 0.82 | — | — | |
| SCHEMBL1276675 | 0.80 | EPHX1 (0.48) | — | |
| SCHEMBL4075630 | 0.78 | — | — | |
| SCHEMBL1625755 | 0.76 | EPHX1 (0.44) | — | |
| SCHEMBL10981737 | 0.76 | — | — | |
| SCHEMBL19680558 | 0.76 | EPHX1 (0.56) | — | |
| SCHEMBL10846291 | 0.76 | — | — | |
| SCHEMBL42512 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936622-B2 | 6-phenylbenzonaphthyridines | ALTANA PHARMA AG (DE) | 2005-08-30 | — | — | US | claimed |
| EP-1377574-B1 | 6-PHENYLBENZONAPHTHYRIDINES | BYK GULDEN LOMBERG CHEM FAB (DE) | 2005-01-19 | — | — | EP | claimed |
| US-20040097537-A1 | 6-phenylbenzonaphthyridines | TAKEDA GMBH (DE) | 2004-05-20 | — | — | US | claimed |
| EP-1377574-B1 | 6-PHENYLBENZONAPHTHYRIDINES | BYK GULDEN LOMBERG CHEM FAB (DE) | 2005-01-19 | — | — | EP | disclosed |
| EP-0228192-A2 | Renin-inhibitory oligopeptides, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1987-07-08 | — | — | EP | disclosed |