⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6440895 | 0.82 | — | — | |
| SCHEMBL10455578 | 0.80 | — | — | |
| SCHEMBL5842289 | 0.78 | EPHX1 (0.56) | — | |
| SCHEMBL1273741 | 0.78 | MMP1 (0.40) | — | |
| SCHEMBL21653841 | 0.77 | — | — | |
| SCHEMBL33565 | 0.75 | — | — | |
| SCHEMBL6439109 | 0.73 | — | — | |
| SCHEMBL23286 | 0.73 | — | — | |
| SCHEMBL7197099 | 0.73 | — | — | |
| SCHEMBL1387293 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936622-B2 | 6-phenylbenzonaphthyridines | ALTANA PHARMA AG (DE) | 2005-08-30 | — | — | US | claimed |
| EP-1377574-B1 | 6-PHENYLBENZONAPHTHYRIDINES | BYK GULDEN LOMBERG CHEM FAB (DE) | 2005-01-19 | — | — | EP | claimed |
| US-20040097537-A1 | 6-phenylbenzonaphthyridines | TAKEDA GMBH (DE) | 2004-05-20 | — | — | US | claimed |
| EP-1377574-A1 | 6-PHENYLBENZONAPHTHYRIDINES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2004-01-07 | — | — | EP | claimed |
| WO-2002066476-A9 | 6-PHENYLBENZONAPHTHYRIDINES | ALTANA PHARMA AG (DE) | 2003-10-30 | — | — | WO | claimed |
| WO-2002066476-A1 | 6-PHENYLBENZONAPHTHYRIDINES | ALTANA PHARMA AG (DE) | 2002-08-29 | — | — | WO | claimed |
| EP-1391454-B1 | Substituted benzamide compounds with antihypertensive activity | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-05-30 | — | — | EP | disclosed |
| WO-2008156656-A2 | METHOD FOR MAKING BIARYL COMPOUNDS, COMPOUNDS MADE BY THE METHOD, AND METHOD FOR THEIR USE | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY (US) | 2008-12-24 | — | — | WO | disclosed |
| US-6936622-B2 | 6-phenylbenzonaphthyridines | ALTANA PHARMA AG (DE) | 2005-08-30 | — | — | US | disclosed |
| EP-1377574-B1 | 6-PHENYLBENZONAPHTHYRIDINES | BYK GULDEN LOMBERG CHEM FAB (DE) | 2005-01-19 | — | — | EP | disclosed |
| US-20040097537-A1 | 6-phenylbenzonaphthyridines | TAKEDA GMBH (DE) | 2004-05-20 | — | — | US | disclosed |
| EP-1391454-A1 | Substituted benzamide compounds with antihypertensive activity | Mitsubishi Pharma Corporation (JP) | 2004-02-25 | — | — | EP | disclosed |
| EP-1377574-A1 | 6-PHENYLBENZONAPHTHYRIDINES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002066476-A9 | 6-PHENYLBENZONAPHTHYRIDINES | ALTANA PHARMA AG (DE) | 2003-10-30 | — | — | WO | disclosed |
| WO-2002066476-A1 | 6-PHENYLBENZONAPHTHYRIDINES | ALTANA PHARMA AG (DE) | 2002-08-29 | — | — | WO | disclosed |
| EP-1195372-A1 | N-heterocyclic substituted benzamide derivatives with antihypertensive activity | Mitsubishi Pharma Corporation (JP) | 2002-04-10 | — | — | EP | disclosed |
| US-6156766-A | Benzamide compounds and pharmaceutical use thereof | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2000-12-05 | — | — | US | disclosed |
| US-5958944-A | TREATMENT OF CIRCULATORY DISEASES IN CORONARY, CEREBRAL, RENAL AND PERIPHERAL ARTERIES, AS A THERAPEUTIC AGENT FOR HYPERTENSION, ANGINA PECTORIS, AND RENAL AND PERIPHERAL CIRCULATION DISORDER, ANTIASTHMATIC AGENT | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0757038-A1 | BENZAMIDE COMPOUND AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |