Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 6/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6444685 | 1.00 | ALDH1A1 (0.56) | ALDH1A1KMT2ATSHRCYP2D6PDE5A | |
| SCHEMBL6446091 | 0.94 | ALDH1A1 (0.58) | ALDH1A1KMT2ATSHRCYP2D6PDE5A | |
| SCHEMBL6446723 | 0.85 | ALDH1A1 (0.59) | ALDH1A1KMT2ATSHRCYP2D6PDE5A | |
| SCHEMBL6447283 | 0.83 | KMT2A (0.56) | ALDH1A1KMT2ATSHRCYP2D6PDE5A | |
| SCHEMBL6443408 | 0.83 | KMT2A (0.56) | ALDH1A1KMT2ATSHRCYP2D6PDE5A | |
| SCHEMBL2402633 | 0.80 | ALDH1A1 (0.70) | ALDH1A1KMT2ATSHRCYP2D6PDE5A | |
| SCHEMBL6444485 | 0.79 | KMT2A (0.68) | ALDH1A1KMT2ACYP2D6PDE5AHTT | |
| SCHEMBL15067526 | 0.79 | BRD4 (0.52) | BRD4 | |
| SCHEMBL6444483 | 0.78 | KMT2A (0.56) | ALDH1A1KMT2ACYP2D6PDE5AHTT | |
| SCHEMBL6442109 | 0.77 | KMT2A (0.58) | ALDH1A1KMT2ATSHRCYP2D6PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1371647-B1 | Pyridine-3-carboxylic acid derivatives and their use as intermediates | PFIZER (US) | 2005-07-13 | — | — | EP | disclosed |
| EP-1371647-A2 | Pyridine-3-carboxylic acid derivatives and their use as intermediates | PFIZER INC. (US) | 2003-12-17 | — | — | EP | disclosed |
| EP-1073658-B1 | PYRAZOLOPYRIMIDINONE CGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER (US) | 2003-08-13 | — | — | EP | disclosed |
| US-6251904-B1 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-06-26 | — | — | US | disclosed |
| EP-1073658-A1 | PYRAZOLOPYRIMIDINONE CGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER INC. (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999054333-A1 | PYRAZOLOPYRIMIDINONE CGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER INC. (US) | 1999-10-28 | — | — | WO | disclosed |