Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | HTR1B | P28222 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | HTR2B | P41595 | 2/20 | 0.51 |
| ▸ | FAAH | O00519 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6445354 | 0.87 | CYP2C9 (0.50) | HTR1AHTR1BHTR2AHTR2CHTR2B | |
| SCHEMBL6442987 | 0.85 | CYP2C9 (0.49) | HTR1AHTR1BHTR2AHTR2CHTR2B | |
| SCHEMBL6458040 | 0.85 | CYP2C9 (0.49) | HTR1AHTR1BHTR2AHTR2CHTR2B | |
| SCHEMBL6442418 | 0.84 | CYP2C9 (0.51) | LMNACYP2C9CYP3A4MAPTKDM4E | |
| SCHEMBL6443286 | 0.84 | CYP2C9 (0.49) | HTR1AHTR1BHTR2AHTR2CHTR2B | |
| SCHEMBL6442104 | 0.82 | CYP2C9 (0.53) | CYP2C9RAB9ACYP3A4KDM4E | |
| SCHEMBL6445721 | 0.82 | CYP2C9 (0.45) | LMNACYP2C9CYP3A4 | |
| SCHEMBL6440978 | 0.81 | CYP2C9 (0.54) | CYP2C9RAB9ACYP3A4KDM4E | |
| SCHEMBL6444101 | 0.81 | CYP2C9 (0.56) | LMNACYP2C9RAB9ACYP3A4MAPT | |
| SCHEMBL6442978 | 0.81 | CYP2C9 (0.51) | LMNACYP2C9MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299382-B1 | COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED INDOLEOXOACETIC PIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2005-09-21 | — | — | EP | claimed |