Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.56 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.56 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5617570 | 0.85 | MAOB (0.60) | MAOBMAOAITGB3ITGA2BGRM5 | |
| SCHEMBL4415125 | 0.84 | ITGB3 (0.78) | MAOBMAOAITGB3ITGA2B | |
| SCHEMBL4420166 | 0.83 | AOC3 (0.59) | MAOBMAOAITGB3ITGA2BGRM5 | |
| SCHEMBL3504172 | 0.83 | ITGB3 (0.68) | MAOBMAOAITGB3ITGA2BAOC3 | |
| SCHEMBL4430022 | 0.83 | MAOB (0.60) | MAOBMAOAITGB3ITGA2BGRM5 | |
| SCHEMBL4424255 | 0.82 | MAOB (0.60) | MAOBMAOAITGB3ITGA2BGRM5 | |
| SCHEMBL4416062 | 0.82 | ITGB3 (0.66) | MAOBMAOAITGB3ITGA2BGRM5 | |
| SCHEMBL4422692 | 0.82 | AOC3 (0.63) | MAOBMAOAITGB3ITGA2BGRM5 | |
| SCHEMBL4428906 | 0.82 | ITGB3 (0.60) | MAOBMAOAITGB3ITGA2BGRM5 | |
| SCHEMBL4420045 | 0.82 | MAOB (0.56) | MAOBMAOAITGB3ITGA2BGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501804-A1 | ISOQUINOLINE DERIVATIVES MAO-B INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091219-A1 | ISOQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-06 | — | — | WO | disclosed |