Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 7/20 | 0.77 |
| ▸ | PSMB5 | P28074 | 7/20 | 0.77 |
| ▸ | PSMB2 | P49721 | 5/20 | 0.77 |
| ▸ | LTA4H | P09960 | 3/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL227699 | 0.98 | PSMB1 (0.75) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| SCHEMBL2741667 | 0.98 | PSMB1 (0.80) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| SCHEMBL1027972 | 0.98 | PSMB1 (0.80) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| Hydrochloric Acid SCHEMBL228100 | 0.97 | PSMB1 (0.78) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| Hydrochloric Acid SCHEMBL228398 | 0.97 | PSMB1 (0.78) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| SCHEMBL7139772 | 0.95 | PSMB1 (0.71) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| SCHEMBL7132076 | 0.95 | PSMB1 (0.71) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| SCHEMBL2344523 | 0.94 | PSMB1 (0.74) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| Hydrochloric Acid SCHEMBL7626127 | 0.93 | PSMB1 (0.72) | PSMB1PSMB5PSMB2LTA4HKDM4E | |
| SCHEMBL2087691 | 0.92 | KDM4E (0.72) | PSMB1PSMB5PSMB2LTA4HKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210047297-A1 | 4-(3-AMINO-6-FLUORO-1H-INDAZOL-5-YL)-1,2,6-TRIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DIC ARBONITRILE COMPOUNDS FOR TREATING HYPERPROLIFERATIVE DISORDERS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2021-02-18 | — | — | US | disclosed |
| EP-3774769-A1 | 4-(3-AMINO-6-FLUORO-1H-INDAZOL-5-YL)-1,2,6-TRIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DIC ARBONITRILE COMPOUNDS FOR TREATING HYPERPROLIFERATIVE DISORDERS | Bayer Pharma Aktiengesellschaft (DE) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019185525-A1 | 4-(3-AMINO-6-FLUORO-1H-INDAZOL-5-YL)-1,2,6-TRIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DIC ARBONITRILE COMPOUNDS FOR TREATING HYPERPROLIFERATIVE DISORDERS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-10-03 | — | — | WO | disclosed |
| WO-2019185525-A1 | 4-(3-AMINO-6-FLUORO-1H-INDAZOL-5-YL)-1,2,6-TRIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DIC ARBONITRILE COMPOUNDS FOR TREATING HYPERPROLIFERATIVE DISORDERS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-10-03 | — | — | WO | disclosed |
| WO-2017001853-A1 | ANTIVIRAL COMPOUNDS | REDX PHARMA PLC (GB) | 2017-01-05 | — | — | WO | disclosed |
| EP-2526116-B1 | PYRUVAMIDE COMPOUNDS AS INHIBITORS OF DUST MITE GROUP 1 PEPTIDASE ALLERGEN | ST GEORGES HOSP MEDICAL SCHOOL (GB) | 2015-05-13 | — | — | EP | disclosed |
| US-8637453-B2 | Pyruvamide compounds as inhibitors of dust mite group 1 peptidase allergen and their use | ST GEORGE'S HOSPITAL MEDICAL SCHOOL (GB) | 2014-01-28 | — | — | US | disclosed |
| US-8637453-B2 | Pyruvamide compounds as inhibitors of dust mite group 1 peptidase allergen and their use | ST GEORGE'S HOSPITAL MEDICAL SCHOOL (GB) | 2014-01-28 | — | — | US | disclosed |
| US-8541363-B2 | Pyruvamide compounds as inhibitors of dust mite group 1 peptidase allergen and their use | St George's Hosptial Medical School (GB) | 2013-09-24 | — | — | US | disclosed |
| US-8541363-B2 | Pyruvamide compounds as inhibitors of dust mite group 1 peptidase allergen and their use | St George's Hosptial Medical School (GB) | 2013-09-24 | — | — | US | disclosed |
| US-4400543-A | ANTIFERTILITY AGENTS | ELI LILLY AND COMPANY (US) | 1983-08-23 | — | — | US | disclosed |
| US-4394313-A | Symmetrical azetidinone aldehyde disulfides and process | ELI LILLY AND COMPANY (US) | 1983-07-19 | — | — | US | disclosed |
| US-4380635-A | Synthesis of acylated benzothiophenes | ELI LILLY AND COMPANY (US) | 1983-04-19 | — | — | US | disclosed |
| US-4358593-A | BY ACYLATION OF PROTECTED 6-HYDROXY,2-(4-HYDROXYPHENYL) BENZO (B)THIOPHENE USING A FRIEDEL CRAFTS CATALYSTS; HYDROLYSIS | ELI LILLY AND COMPANY (US) | 1982-11-09 | — | — | US | disclosed |
| EP-0062504-A1 | Process for preparing 3-(4-aminoethoxybenzoyl)benzo(b)thiophenes | ELI LILLY AND COMPANY (US) | 1982-10-13 | — | — | EP | disclosed |
| EP-0062505-A1 | A process for preparing acylated benzothiophenes | ELI LILLY AND COMPANY (US) | 1982-10-13 | — | — | EP | disclosed |
| US-4323707-A | USEFUL FOR AMIMALS, AROYL-PHENYL-NAPHTHALENES OR DIHYDRONAPHTHALENES | ELI LILLY AND COMPANY (US) | 1982-04-06 | — | — | US | disclosed |
| US-4293495-A | Symmetrical azetidinone aldehyde disulfides and process | ELI LILLY AND COMPANY (US) | 1981-10-06 | — | — | US | disclosed |
| US-4230862-A | 3-PHENYL-4-AROYL-1,2-DIHYDRONAPHTHALENES AND 1-ARYOYL-2-PHENYLNAPHTHALENES | ELI LILLY AND COMPANY (US) | 1980-10-28 | — | — | US | disclosed |
| US-4133814-A | ANTITUMOR AGENTS | ELI LILLY AND COMPANY (US) | 1979-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210047297-A1 | 4-(3-AMINO-6-FLUORO-1H-INDAZOL-5-YL)-1,2,6-TRIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DIC ARBONITRILE COMPOUNDS FOR TREATING HYPERPROLIFERATIVE DISORDERS | PKD1, CDKN1A, VHL | PSMB1 2640/4885PSMB5 1495/4885PSMB2 2966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.