SCHEMBL6443337

SCHEMBL6443337

N#Cc1c(F)c(Cl)c(F)c(Cl)c1F

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.48
ALDH1A1 P00352 1/20 0.48
TP53 P04637 1/20 0.48
CYP3A4 P08684 1/20 0.48
MAPT P10636 1/20 0.48
HPGD P15428 1/20 0.48
MAPK1 P28482 1/20 0.48
KMT2A Q03164 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
TRPV4 Q9HBA0 1/20 0.33
KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1793668 0.94 MEN1 (0.48) MEN1ALDH1A1TP53CYP3A4MAPT
SCHEMBL23723913 0.92 MEN1 (0.62) MEN1ALDH1A1TP53CYP3A4MAPT
SCHEMBL6446552 0.89 MEN1 (0.43) MEN1ALDH1A1TP53CYP3A4MAPT
SCHEMBL6446650 0.88 MEN1 (0.55) MEN1ALDH1A1TP53CYP3A4MAPT
SCHEMBL8047840 0.88 MEN1 (0.55) MEN1ALDH1A1TP53CYP3A4MAPT
SCHEMBL10756123 0.86 ALDH1A1 (0.46) MEN1ALDH1A1TP53CYP3A4MAPT
SCHEMBL10825637 0.86 MEN1 (0.46) MEN1ALDH1A1TP53CYP3A4MAPT
SCHEMBL19021269 0.85 MEN1 (0.50) MEN1ALDH1A1TP53CYP3A4MAPT
SCHEMBL31609232 0.85 ALDH1A1 (0.50) MEN1ALDH1A1TP53CYP3A4MAPT
SCHEMBL5674848 0.83 MEN1 (0.50) MEN1ALDH1A1TP53CYP3A4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119431155-A Method for synthesizing 2,4, 6-trifluoro-benzylamine by one-pot method 浙江永太科技股份有限公司 2025-02-14 CN claimed
CN-114163296-B Preparation method of 1, 3-dichloro-2, 4, 6-trifluorobenzene 阜新睿光氟化学有限公司 2023-10-13 CN claimed
CN-112608220-B Synthetic method of 3, 5-difluorophenol 浙江中欣氟材股份有限公司 2022-06-07 CN claimed
CN-112457197-B Preparation method of compound 2, 4, 6-trifluorobenzylamine 浙江丽晶化学有限公司 2022-05-13 CN claimed
CN-114163296-A Preparation method of 1, 3-dichloro-2, 4, 6-trifluorobenzene 阜新睿光氟化学有限公司 2022-03-11 CN claimed
WO-2021156893-A1 PROCESS FOR PREPARATION OF 2,4,6-TRIFLUOROBENZOIC ACID SRF LIMITED (IN) 2021-08-12 WO claimed
CN-112457197-A Preparation method of compound 2, 4, 6-trifluorobenzylamine 浙江丽晶化学有限公司 2021-03-09 CN claimed
CN-107778183-B Preparation method of 2,4, 6-trifluorobenzylamine 杭州澳赛诺生物科技有限公司 2020-05-22 CN claimed
CN-108586267-A A kind of preparation method of tri- fluorin benzyl amines of 2,4,6- 浙江中欣氟材股份有限公司 2018-09-28 CN claimed
JP-61030556-A None JP disclosed
JP-61022059-A None JP disclosed
JP-61036244-A None JP disclosed
JP-60094919-A None JP disclosed
CN-119431155-A Method for synthesizing 2,4, 6-trifluoro-benzylamine by one-pot method 浙江永太科技股份有限公司 2025-02-14 CN disclosed
US-4684734-A Method for manufacture or organic fluorine compounds NIPPON SHOKUBAI KK CO., LTD. (JP) 1987-08-04 US disclosed
JP-S6136244-A PRODUCTION OF 2,4,6-TRIFLUOROBENZOIC ACID NIPPON SHOKUBAI KAGAKU KOGYO CO LTD 1986-02-20 JP disclosed
JP-S6130556-A PRODUCTION OF 2,4,6-TRIFLUOROBENZOIC ACID NIPPON SHOKUBAI KAGAKU KOGYO CO LTD 1986-02-12 JP disclosed
JP-S6122059-A 2,4,6-TRIFLUOROBENZONITRILE AND ITS PREPARATION NIPPON SHOKUBAI KAGAKU KOGYO CO LTD 1986-01-30 JP disclosed
JP-S6094919-A PRODUCTION OF ORGANIC FLUORIDE NIPPON SHOKUBAI KAGAKU KOGYO CO LTD 1985-05-28 JP disclosed
EP-0120575-A1 Organic fluorine compounds Nippon Shokubai Kagaku Kogyo Co., Ltd (JP) 1984-10-03 EP disclosed