Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | EBP | Q15125 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL6440321 | 0.88 | HRH1 (0.56) | HRH1SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL6030546 | 0.85 | HRH1 (0.72) | HRH1SIGMAR1HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL6440622 | 0.84 | HRH1 (0.73) | HRH1HTR2AHTR2C | |
| SCHEMBL6440008 | 0.73 | HRH1 (0.80) | HRH1SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL6031708 | 0.72 | HRH1 (0.71) | HRH1SIGMAR1HTR2AHTR2CHTR2B | |
| Water SCHEMBL6031226 | 0.72 | HRH1 (0.78) | HRH1SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL6031874 | 0.69 | SIGMAR1 (0.49) | HRH1SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL6029703 | 0.69 | HRH1 (0.77) | HRH1SIGMAR1HTR2AHTR2CHTR2B | |
| Vapitadine SCHEMBL29379463 | 0.69 | HRH1 (1.00) | HRH1SIGMAR1HTR2AHTR2CHTR2B | |
| Vapitadine SCHEMBL6440903 | 0.69 | HRH1 (1.00) | HRH1SIGMAR1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144411-B1 | ANTIHISTAMINIC SPIRO COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2005-04-27 | — | — | EP | claimed |