Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | SDCBP | O00560 | 3/20 | 0.49 |
| ▸ | SDC2 | P34741 | 3/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.46 |
| ▸ | FNTB | P49356 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PHF8 | Q9UPP1 | 5/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | KDM5C | P41229 | 3/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GNPAT | O15228 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6443939 | 1.00 | NPSR1 (0.51) | NPSR1SDCBPSDC2PLA2G2APLA2G5 | |
| SCHEMBL6444700 | 0.88 | PLA2G2A (0.51) | NPSR1SDCBPSDC2PLA2G2APLA2G5 | |
| SCHEMBL29901839 | 0.88 | EPHX2 (0.50) | NPSR1SDCBPSDC2PLA2G2APLA2G5 | |
| SCHEMBL6444706 | 0.88 | PLA2G2A (0.51) | NPSR1SDCBPSDC2PLA2G2APLA2G5 | |
| SCHEMBL6448445 | 0.86 | PLA2G2A (0.54) | NPSR1SDCBPSDC2PLA2G2APLA2G5 | |
| Hydrochloric Acid SCHEMBL29901850 | 0.86 | EPHX2 (0.49) | NPSR1SDCBPSDC2PLA2G2APLA2G5 | |
| SCHEMBL6448450 | 0.86 | PLA2G2A (0.54) | NPSR1SDCBPSDC2PLA2G2APLA2G5 | |
| SCHEMBL26620701 | 0.86 | NPSR1 (0.41) | NPSR1SDCBPSDC2PLA2G2APLA2G5 | |
| SCHEMBL26620698 | 0.86 | NPSR1 (0.41) | NPSR1SDCBPSDC2PLA2G2APLA2G5 | |
| SCHEMBL19197747 | 0.86 | NPSR1 (0.42) | NPSR1SDCBPSDC2EPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050130941-A1 | Methods of treating alzheimer's disease | PHARMACIA & UPJOHN COMPANY LLC | 2005-06-16 | — | — | US | disclosed |
| EP-1392315-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002100410-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-12-19 | — | — | WO | disclosed |
| US-5753652-A | Antiretroviral hydrazine derivatives | NOVARTIS CORPORATION (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0521827-B1 | Pharmacological active hydrazin derivatives and process for their preparation | CIBA GEIGY AG (CH) | 1996-09-25 | — | — | EP | disclosed |
| EP-0521827-A1 | Pharmacological active hydrazin derivatives and process for their preparation | CIBA-GEIGY AG (CH) | 1993-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130941-A1 | Methods of treating alzheimer's disease | BACE1, PSEN1, BACE2 | NPSR1 542/4885SDCBP 3079/4885SDC2 3257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.