Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 6/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10527514 | 0.87 | CYP2C9 (0.40) | CA9GAACYP2C9CA12CA1 | |
| SCHEMBL253350 | 0.83 | CYP2C9 (0.48) | CA9CYP2C9CA12CA1CA2 | |
| SCHEMBL10690222 | 0.81 | CA9 (0.46) | CA9GAACYP2C9CA12CA1 | |
| SCHEMBL3354585 | 0.81 | NSD2 (0.54) | CYP2C9KDM4ECYP1A2CYP2D6CASP1 | |
| SCHEMBL4070788 | 0.79 | TSHR (0.49) | CYP2C9KDM4ECYP1A2CYP2D6CASP1 | |
| SCHEMBL11667123 | 0.79 | KDM4E (0.54) | CA9CYP2C9CA12CA1CA2 | |
| SCHEMBL10616445 | 0.79 | KDM4E (0.45) | CA9CYP2C9CA12CA1CA2 | |
| SCHEMBL16831449 | 0.79 | RECQL (0.53) | CYP2C9CA1CA2CA4CA6 | |
| SCHEMBL4564656 | 0.78 | KDM4E (0.44) | CA9CYP2C9CA12CA1CA2 | |
| SCHEMBL18937244 | 0.77 | NPSR1 (0.46) | CA9CYP2C9CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |
| EP-1175406-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066563-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-11-09 | — | — | WO | disclosed |
| US-5830975-A | BLEND WITH HYDROXY-FUNCTIONAL POLYMER, ESPECIALLY ETHYLENE-VINYL ALCOHOL COPOLYMER | ELF ATOCHEM S.A. (FR) | 1998-11-03 | — | — | US | disclosed |
| US-5409999-A | For wetting, coating metal surfaces | ELF ATOCHEM S.A. (FR) | 1995-04-25 | — | — | US | disclosed |