SCHEMBL6444019

SCHEMBL6444019

C[Si](C)=[Zr](Cl)(Cl)(C1C=Cc2ccccc21)C1c2ccccc2-c2cccc(OCCO)c21

nearest known ligand 0.31

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
KEAP1 Q14145 2/20 0.30
LMNA P02545 1/20 0.30
POLB P06746 1/20 0.30
NFE2L2 Q16236 1/20 0.30
HTR7 P34969 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6447716 0.86 MEN1 (0.36) MEN1KMT2AKEAP1LMNAPOLB
SCHEMBL6066599 0.85
SCHEMBL6445095 0.85 MEN1 (0.31) MEN1KMT2AKEAP1LMNAPOLB
SCHEMBL6447652 0.84
SCHEMBL6527109 0.83
SCHEMBL7935566 0.80 SLC22A2 (0.33) MEN1KMT2ALMNA
SCHEMBL6447932 0.74 MEN1 (0.36) MEN1KMT2AKEAP1LMNAPOLB
SCHEMBL376490 0.72 HTR2A (0.36) MEN1KMT2ALMNA
SCHEMBL7636017 0.72
SCHEMBL6066786 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050065018-A1 Preparation and use of heterogeneous catalyst components for olefins polymerization (1) REPSOL QUIMICA S.A. 2005-03-24 US disclosed
EP-0953580-B1 Preparation and use of heterogeneous catalyst components for olefins polymerization REPSOL QUIMICA SA (ES) 2004-04-14 EP disclosed
US-20030144135-A1 PREPARATION AND USE OF HETEROGENEOUS CATALYST COMPONENTS FOR OLEFINS POLYMERIZATION REPSOL QUIMICA S.A. (ES) 2003-07-31 US disclosed
EP-0955306-B1 Functionalized metallocene compounds, synthesis process and use thereof REPSOL QUIMICA SA (ES) 2003-01-22 EP disclosed
US-6114555-A Functionalized metallocene compounds, synthesis process and use thereof REPSOL QUIMICA S.A. (ES) 2000-09-05 US disclosed
EP-0955306-A1 Functionalized metallocene compounds, synthesis process and use thereof REPSOL QUIMICA S.A. (ES) 1999-11-10 EP disclosed
EP-0953580-A1 Preparation and use of heterogeneous catalyst components for olefins polymerization REPSOL QUIMICA S.A. (ES) 1999-11-03 EP disclosed