Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.59 |
| ▸ | SRC | P12931 | 3/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 12/20 | 0.59 |
| ▸ | EPHB4 | P54760 | 9/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.57 |
| ▸ | CSK | P41240 | 1/20 | 0.55 |
| ▸ | TEK | Q02763 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 4/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | KIF5B | P33176 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6452733 | 0.94 | KDR (0.62) | KDRSRCEPHA2EPHB4ERBB2 | |
| SCHEMBL6445304 | 0.83 | KDR (0.66) | KDRSRCEPHA2EPHB4ERBB2 | |
| SCHEMBL2136783 | 0.83 | EGFR (0.74) | KDRSRCEPHA2EPHB4ERBB2 | |
| SCHEMBL3204055 | 0.82 | KDR (0.61) | KDRSRCEPHA2EPHB4ERBB2 | |
| SCHEMBL3131165 | 0.80 | EGFR (0.75) | KDRSRCEPHA2EPHB4ERBB2 | |
| SCHEMBL6445635 | 0.80 | KDR (0.67) | KDRSRCEPHA2EPHB4ERBB2 | |
| SCHEMBL6445629 | 0.80 | KDR (0.67) | KDRSRCEPHA2EPHB4ERBB2 | |
| SCHEMBL2136853 | 0.80 | KDR (0.74) | KDRSRCEPHA2EPHB4ERBB2 | |
| SCHEMBL17179598 | 0.79 | KDR (0.65) | KDRSRCEPHA2EPHB4ERBB2 | |
| SCHEMBL17179600 | 0.79 | EPHA2 (0.52) | KDRSRCEPHA2EPHB4ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849625-B2 | Quinazoline derivatives with anti-tumour activity | ASTRAZENECA AB (SE) | 2005-02-01 | — | — | US | disclosed |
| US-20040048881-A1 | Quinazoline derivatives with anti-tumour activity | ASTRAZENECA AB (SE) | 2004-03-11 | — | — | US | disclosed |
| EP-1326859-A1 | QUINAZOLINE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | AstraZeneca AB (SE) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002030924-A9 | QUINAZOLINE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB (SE) | 2003-05-22 | — | — | WO | disclosed |
| WO-2002030924-A1 | QUINAZOLINE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB (SE) | 2002-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048881-A1 | Quinazoline derivatives with anti-tumour activity | TOP1, NQO2, ABCC1 | KDR 2192/4885SRC 2823/4885EPHA2 3999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.