Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.66 |
| ▸ | EGFR | P00533 | 7/20 | 0.66 |
| ▸ | FLT1 | P17948 | 6/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.66 |
| ▸ | FLT4 | P35916 | 5/20 | 0.66 |
| ▸ | SRC | P12931 | 4/20 | 0.64 |
| ▸ | EPHA2 | P29317 | 8/20 | 0.59 |
| ▸ | EPHB4 | P54760 | 8/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.59 |
| ▸ | CSK | P41240 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.55 |
| ▸ | MERTK | Q12866 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6445791 | 0.92 | KDR (0.66) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL7252484 | 0.88 | KDR (0.66) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL6445635 | 0.87 | KDR (0.67) | KDRFLT1SRCEPHA2EPHB4 | |
| SCHEMBL6445629 | 0.87 | KDR (0.67) | KDRFLT1SRCEPHA2EPHB4 | |
| SCHEMBL7251995 | 0.86 | KDR (0.56) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL6444241 | 0.83 | KDR (0.59) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL6451233 | 0.83 | KDR (0.44) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL7171308 | 0.83 | KDR (0.67) | KDRFLT1SRCEPHA2EPHB4 | |
| Hydrochloric Acid SCHEMBL5215634 | 0.82 | KDR (0.80) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL6448818 | 0.81 | KDR (0.67) | KDREGFRFLT1SRCEPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849625-B2 | Quinazoline derivatives with anti-tumour activity | ASTRAZENECA AB (SE) | 2005-02-01 | — | — | US | disclosed |
| US-20040048881-A1 | Quinazoline derivatives with anti-tumour activity | ASTRAZENECA AB (SE) | 2004-03-11 | — | — | US | disclosed |
| EP-1326859-A1 | QUINAZOLINE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | AstraZeneca AB (SE) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002030924-A9 | QUINAZOLINE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB (SE) | 2003-05-22 | — | — | WO | disclosed |
| WO-2002030924-A1 | QUINAZOLINE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB (SE) | 2002-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048881-A1 | Quinazoline derivatives with anti-tumour activity | TOP1, NQO2, ABCC1 | KDR 2192/4885EGFR 2315/4885FLT1 547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.