Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 7/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.46 |
| ▸ | FAP | Q12884 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.39 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4664775 | 0.86 | DPP4 (0.45) | DPP4DPP8DPP9DPP7SPHK2 | |
| SCHEMBL4664760 | 0.84 | DPP4 (0.51) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL6444430 | 0.82 | DPP4 (0.67) | DPP4DPP8DPP9DPP7 | |
| SCHEMBL6449836 | 0.81 | POLB (0.47) | — | |
| SCHEMBL4665023 | 0.80 | DPP4 (0.48) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL2260961 | 0.77 | CHRNB4 (0.50) | SPHK2METAP2ABHD6DAGLA | |
| SCHEMBL4958145 | 0.76 | DPP4 (0.50) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL6442733 | 0.76 | DPP4 (0.55) | DPP4FAAHSPHK2SPHK1 | |
| SCHEMBL8288214 | 0.75 | DPP4 (0.68) | DPP4DPP8DPP9DPP7 | |
| SCHEMBL8290104 | 0.74 | DPP4 (0.60) | DPP4DPP8DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1604662-A1 | 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus | Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft (DE) | 2005-12-14 | — | — | EP | disclosed |