Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6444432 | 0.81 | DPP4 (0.46) | — | |
| SCHEMBL5662424 | 0.74 | GHSR (0.51) | GRIN2C | |
| SCHEMBL6444422 | 0.70 | SCN8A (0.38) | TP53 | |
| SCHEMBL4664775 | 0.68 | DPP4 (0.45) | — | |
| SCHEMBL4664760 | 0.66 | DPP4 (0.51) | — | |
| SCHEMBL6449835 | 0.66 | DPP4 (0.50) | — | |
| SCHEMBL6444430 | 0.66 | DPP4 (0.67) | — | |
| SCHEMBL26065132 | 0.65 | GRIN2C (0.64) | GRIN2C | |
| SCHEMBL23436233 | 0.65 | CHRM3 (0.70) | — | |
| SCHEMBL23436348 | 0.65 | CHRM3 (0.70) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1604662-A1 | 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus | Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft (DE) | 2005-12-14 | — | — | EP | disclosed |