Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | CTSG | P08311 | 2/20 | 0.33 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.33 |
| ▸ | CMA1 | P23946 | 2/20 | 0.33 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15184990 | 1.00 | MMP13 (0.36) | MMP13PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL16414800 | 0.85 | BLM (0.38) | PRSS1CTSGCTRB1CMA1CYP24A1 | |
| SCHEMBL15271471 | 0.85 | BLM (0.38) | PRSS1CTSGCTRB1CMA1CYP24A1 | |
| SCHEMBL6449609 | 0.85 | BLM (0.38) | PRSS1CTSGCTRB1CMA1CYP24A1 | |
| SCHEMBL12549853 | 0.84 | PRSS1 (0.33) | PRSS1CTSGCTRB1CMA1CYP24A1 | |
| SCHEMBL27318265 | 0.83 | TSHR (0.36) | TSHRPPARA | |
| SCHEMBL7552716 | 0.83 | PRSS1 (0.34) | PRSS1CTSGCTRB1CMA1CYP24A1 | |
| SCHEMBL7552725 | 0.83 | PRSS1 (0.34) | PRSS1CTSGCTRB1CMA1CYP24A1 | |
| SCHEMBL4494128 | 0.83 | PRSS1 (0.34) | PRSS1CTSGCTRB1CMA1CYP24A1 | |
| SCHEMBL4494121 | 0.83 | PRSS1 (0.34) | PRSS1CTSGCTRB1CMA1CYP24A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-B1 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LAB (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-0402646-B1 | Retroviral protease inhibiting compounds | ABBOTT LAB (US) | 1998-07-22 | — | — | EP | disclosed |
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| US-5142056-A | Human immunodeficiency virus protease inhibitor | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0402646-A1 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-12-19 | — | — | EP | disclosed |