Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | UGCG | Q16739 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 4/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6448061 | 0.98 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1UGCGNPC1RAB9A | |
| SCHEMBL5564059 | 0.83 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2L3MBTL1CNR2 | |
| SCHEMBL5563050 | 0.83 | RXFP1 (0.45) | UGCGNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL5564192 | 0.82 | RXFP1 (0.46) | UGCGNPC1SMN1; SMN2HRH3ALDH1A1 | |
| SCHEMBL5565724 | 0.81 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2L3MBTL1CNR2 | |
| SCHEMBL5564847 | 0.81 | RXFP1 (0.44) | UGCGNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL5564958 | 0.80 | RXFP1 (0.45) | UGCGNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL5559654 | 0.80 | RXFP1 (0.54) | NPC1CNR2ALDH1A1KMT2ADRD2 | |
| SCHEMBL5563555 | 0.79 | RAB9A (0.44) | NPC1RAB9ASMN1; SMN2L3MBTL1CNR2 | |
| SCHEMBL5566157 | 0.79 | RAB9A (0.41) | UGCGNPC1RAB9ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594857-A2 | N-MONOACYLATED O-PHENYLENEDIAMINES AS ANTI-CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004069133-A2 | N-MONOACYLATED O-PHENYLENEDIAMINES AS ANTI -CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-19 | — | — | WO | disclosed |