Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 19/20 | 0.56 |
| ▸ | MMP9 | P14780 | 19/20 | 0.56 |
| ▸ | MMP8 | P22894 | 2/20 | 0.52 |
| ▸ | MMP13 | P45452 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6462509 | 0.88 | MMP2 (0.60) | MMP2MMP9MMP8MMP13 | |
| SCHEMBL726770 | 0.88 | MMP2 (0.69) | MMP2MMP9MMP8MMP13 | |
| SCHEMBL728143 | 0.86 | MMP2 (0.57) | MMP2MMP9MMP8MMP13 | |
| SCHEMBL2532335 | 0.86 | MMP2 (0.67) | MMP2MMP9MMP8MMP13 | |
| SCHEMBL6442962 | 0.84 | MMP2 (0.55) | MMP2MMP9MMP8MMP13 | |
| SCHEMBL6448394 | 0.84 | MMP2 (0.52) | MMP2MMP9MMP8MMP13HRH3 | |
| SCHEMBL728404 | 0.82 | MMP2 (0.53) | MMP2MMP9MMP8MMP13 | |
| SCHEMBL6449006 | 0.80 | MMP2 (0.53) | MMP2MMP9MMP8MMP13 | |
| SCHEMBL6461739 | 0.73 | MMP2 (0.66) | MMP2MMP9MMP8MMP13 | |
| SCHEMBL6445883 | 0.72 | MMP2 (0.54) | MMP2MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226128-B1 | NEW PYRIMIDINE-2,4,6-TRIONE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2005-02-23 | — | — | EP | disclosed |