Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.83 |
| ▸ | CA2 | P00918 | 1/20 | 0.83 |
| ▸ | CA9 | Q16790 | 1/20 | 0.83 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | LDHA | P00338 | 2/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | LDHB | P07195 | 1/20 | 0.36 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.33 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11138540 | 1.00 | CA1 (0.83) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL43480 | 1.00 | — | — | |
| Bicarbonate SCHEMBL6445891 | 1.00 | — | — | |
| Bicarbonate SCHEMBL27835183 | 1.00 | — | — | |
| Bicarbonate SCHEMBL31679605 | 1.00 | CA1 (0.83) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL3967217 | 1.00 | — | — | |
| Bicarbonate SCHEMBL1778895 | 0.93 | — | — | |
| Bicarbonate SCHEMBL1784248 | 0.93 | — | — | |
| Bicarbonate SCHEMBL21815794 | 0.93 | — | — | |
| Bicarbonate SCHEMBL21059474 | 0.93 | CA1 (0.71) | CA1CA2CA9FFAR3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6896909-B2 | Formulations containing iron ores for the topical treatment of bioenergetic and electromagnetic disorders | GEOMEDICAL S.R.L. (IT) | 2005-05-24 | — | — | US | claimed |
| WO-2022158591-A1 | THERAPEUTIC AGENT FOR HYPERTROPHIC CARDIOMYOPATHY | 学校法人順天堂 | 2022-07-28 | — | — | WO | disclosed |
| CN-103464273-B | Process for sorting iron-carbonate-containing low-grade iron ore concentrate | ANSHAN IRON & STEEL GR MINING | 2015-03-11 | — | — | CN | disclosed |
| US-20140134290-A1 | ANIMAL FEED ADDITIVES | Inco Digestive, Inc. (US) | 2014-05-15 | — | — | US | disclosed |
| CN-103464273-A | Process for sorting iron-carbonate-containing low-grade iron ore concentrate | ANSHAN IRON & STEEL GR MINING | 2013-12-25 | — | — | CN | disclosed |
| CN-102728453-B | New technology for sorting lean hematite and magnetite orecontaining iron carbonate | ANSHAN IRON & STEEL GR MINING | 2013-08-07 | — | — | CN | disclosed |
| WO-2013012657-A1 | ANIMAL FEED ADDITIVES | INCO DIGESTIVE, LLC (US) | 2013-01-24 | — | — | WO | disclosed |
| US-20130022706-A1 | Animal Feed Additive | INCO DIGESTIVE, LLC (US) | 2013-01-24 | — | — | US | disclosed |