SCHEMBL6446157

SCHEMBL6446157

CCc1c(C)[nH]c2c(C)ccc(C)c12

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.61
CYP3A4 P08684 1/20 0.61
CYP2C19 P33261 1/20 0.61
KDM4E B2RXH2 8/20 0.41
MAPT P10636 6/20 0.41
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
GAA P10253 1/20 0.38
HTT P42858 1/20 0.37
POLB P06746 3/20 0.37
AHR P35869 1/20 0.35
HSD17B10 Q99714 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
LMNA P02545 1/20 0.33
ALDH1A1 P00352 4/20 0.32
MCL1 Q07820 1/20 0.32
RXFP1 Q9HBX9 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.31
HPGD P15428 1/20 0.31
ALOX15 P16050 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4560753 0.85 CYP1A2 (0.46) CYP1A2CYP3A4CYP2C19KDM4EMAPT
SCHEMBL9964974 0.85 CYP1A2 (0.46) CYP1A2CYP3A4CYP2C19KDM4EMAPT
SCHEMBL9937009 0.79 CYP1A2 (0.42) CYP1A2CYP3A4CYP2C19KDM4EMAPT
SCHEMBL4561364 0.75 CYP1A2 (0.68) CYP1A2CYP3A4CYP2C19KDM4EMAPT
SCHEMBL4744827 0.74 CYP1A2 (0.73) CYP1A2CYP3A4CYP2C19KDM4EMAPT
SCHEMBL26228926 0.74 CYP1A2 (0.41) CYP1A2CYP3A4CYP2C19KDM4EMAPT
SCHEMBL6461121 0.73 AHR (0.50) CYP1A2CYP3A4CYP2C19KDM4EMAPT
SCHEMBL1920877 0.72 HTT (0.50) CYP1A2CYP3A4KDM4EMAPTMEN1
SCHEMBL21765582 0.71 MAPT (0.54) CYP1A2CYP3A4CYP2C19KDM4EMAPT
SCHEMBL13494711 0.71 CYP1A2 (0.44) CYP1A2CYP3A4CYP2C19KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012065062-A1 NOVEL ANTIVIRAL COMPOUNDS PHARMARESOURCES(SHANGHAI)CO., LTD. (CN) 2012-05-18 WO disclosed