Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380845 | 0.88 | CYP1A2 (0.57) | CYP1A2CYP3A4CYP2C19KDM4EMAPT | |
| SCHEMBL3639386 | 0.88 | CYP1A2 (0.57) | CYP1A2CYP3A4CYP2C19KDM4EMAPT | |
| SCHEMBL3381299 | 0.88 | CYP1A2 (0.57) | CYP1A2CYP3A4CYP2C19KDM4EMAPT | |
| SCHEMBL3802469 | 0.78 | KDM4E (0.47) | CYP1A2CYP3A4CYP2C19KDM4EMAPT | |
| SCHEMBL3264986 | 0.78 | MAPT (0.75) | CYP1A2CYP3A4CYP2C19KDM4EMAPT | |
| SCHEMBL3638375 | 0.78 | CYP1A2 (0.45) | CYP1A2CYP3A4CYP2C19KDM4EMAPT | |
| SCHEMBL6446157 | 0.74 | CYP1A2 (0.61) | CYP1A2CYP3A4CYP2C19KDM4EMAPT | |
| SCHEMBL4558999 | 0.73 | CYP1A2 (0.77) | CYP1A2CYP3A4CYP2C19KDM4EMAPT | |
| SCHEMBL3262617 | 0.73 | CYP1A2 (0.45) | CYP1A2CYP3A4CYP2C19KDM4EMAPT | |
| SCHEMBL3639755 | 0.73 | CYP1A2 (0.41) | CYP1A2CYP3A4CYP2C19KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008099165-A1 | PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2008-08-21 | — | — | WO | claimed |