Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5844619 | 0.87 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL5845315 | 0.84 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL5599990 | 0.78 | CRHR1 (0.67) | CRHR1 | |
| SCHEMBL13696499 | 0.74 | NISCH (0.49) | TP53MEN1NPC1TSHRRAB9A | |
| SCHEMBL21447169 | 0.70 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL21447165 | 0.70 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL27925565 | 0.69 | CYP1A2 (0.45) | TP53MEN1NPC1TSHRRAB9A | |
| SCHEMBL5846010 | 0.69 | CRHR1 (0.78) | CRHR1 | |
| Propane SCHEMBL28061941 | 0.68 | TSHR (0.58) | MEN1NPC1TSHRRAB9AKMT2A | |
| SCHEMBL21447293 | 0.67 | CRHR1 (0.37) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |