Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.58 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16828784 | 0.90 | MKNK1 (0.51) | MKNK1MKNK2MAP3K5SLC6A4HTR6 | |
| SCHEMBL23889124 | 0.84 | DGAT1 (0.45) | MKNK1MKNK2SLC6A4DGAT1 | |
| SCHEMBL20646901 | 0.84 | DGAT1 (0.45) | MKNK1MKNK2SLC6A4DGAT1 | |
| SCHEMBL6451281 | 0.83 | MKNK1 (0.58) | MKNK1MKNK2MAP3K5SLC6A4 | |
| SCHEMBL6456150 | 0.83 | MKNK1 (0.58) | MKNK1MKNK2MAP3K5 | |
| SCHEMBL4233748 | 0.81 | MKNK1 (0.58) | MKNK1MKNK2MAP3K5 | |
| SCHEMBL6447930 | 0.81 | MKNK1 (0.56) | MKNK1MKNK2MAP3K5 | |
| SCHEMBL6450267 | 0.81 | MAP3K5 (0.61) | MKNK1MKNK2MAP3K5SLC6A4 | |
| SCHEMBL15566704 | 0.77 | MAP3K5 (0.54) | MKNK1MKNK2MAP3K5 | |
| SCHEMBL19128145 | 0.76 | DGAT1 (0.43) | MKNK1MKNK2SLC6A4DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6964974-B2 | 2,3-oxidosqualene-lanosterol cyclase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2005-11-15 | — | — | US | disclosed |