SCHEMBL6446355

SCHEMBL6446355

O=C(O)/C=C/C1=CC=CC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 5/20 0.39
HDAC3 O15379 2/20 0.39
HDAC4 P56524 2/20 0.39
HDAC1 Q13547 2/20 0.39
HDAC7 Q8WUI4 2/20 0.39
HDAC2 Q92769 2/20 0.39
HDAC10 Q969S8 2/20 0.39
HDAC11 Q96DB2 2/20 0.39
HDAC8 Q9BY41 2/20 0.39
HDAC6 Q9UBN7 2/20 0.39
HDAC9 Q9UKV0 2/20 0.39
HDAC5 Q9UQL6 2/20 0.39
TNKS O95271 1/20 0.39
TNKS2 Q9H2K2 1/20 0.39
CA1 P00915 3/20 0.36
CA2 P00918 3/20 0.36
CA4 P22748 3/20 0.36
PKM P14618 2/20 0.36
CA12 O43570 2/20 0.36
AKR1B10 O60218 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL183861 1.00 HCAR2 (0.39) HCAR2HDAC3HDAC4HDAC1HDAC7
SCHEMBL3133219 0.93 HCAR2 (0.34) HCAR2HDAC3HDAC4HDAC1HDAC7
SCHEMBL9605416 0.83 GLA (0.41) KDM4EALDH1A1SMN1; SMN2PTGS1KMT2A
SCHEMBL9605417 0.83 GLA (0.41) KDM4EALDH1A1SMN1; SMN2PTGS1KMT2A
SCHEMBL975247 0.80 HCAR2 (0.36) HCAR2HDAC3HDAC4HDAC1HDAC7
SCHEMBL975246 0.80 HCAR2 (0.36) HCAR2HDAC3HDAC4HDAC1HDAC7
SCHEMBL16367424 0.79
SCHEMBL32689424 0.78 MAPT (0.53) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL1918197 0.75 HCAR2 (0.35) HCAR2HDAC3HDAC4HDAC1HDAC7
Maleic Acid SCHEMBL27995249 0.74 TSHR (0.41) HCAR2HDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220153786-A1 PEPTIDES FOR PREVENTING BIOFILM FORMATION UNIVERSITE DE RENNES 1 (FR) 2022-05-19 US disclosed
US-20160312385-A1 Nanofibers Containing Photocurable Ester Derivative of Hyaluronic Acid or Its Salt, Photocured Nanofibers, Method of Synthesis Thereof, Preparation Containing Photocured Nanofibers and Use Thereof CONTIPRO A.S. (CZ) 2016-10-27 US disclosed
US-20140367277-A1 ELECTROCHEMICAL SENSORS SCHLUMBERGER TECHNOLOGY CORPORATION 2014-12-18 US disclosed
EP-2054411-B1 NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AMOREPACIFIC CORP (KR) 2014-08-20 EP disclosed
WO-2013093888-A1 ELECTROCHEMICAL SENSORS SCHLUMBERGER TECHNOLOGY B.V. (NL) 2013-06-27 WO disclosed
EP-1597316-A1 USE OF COMPOSITIONS BASED ON IMPACT-RESISTANT MODIFIED POLYALKYLENE TEREPHTALATE/POLYCARBONATE BLENDS FOR PRODUCING MOLDED BODIES Bayer MaterialScience AG (DE) 2005-11-23 EP disclosed
WO-2004074377-A1 USE OF COMPOSITIONS BASED ON IMPACT-RESISTANT MODIFIED POLYALKYLENE TEREPHTALATE/POLYCARBONATE BLENDS FOR PRODUCING MOLDED BODIES BAYER MATERIALSCIENCE AG (DE) 2004-09-02 WO disclosed
US-6515869-B2 Supporting substrate for a semiconductor bare chip NEC CORPORATION (JP) 2003-02-04 US disclosed
US-20020092610-A1 SUPPORTING SUBSTRATE TO BE BONDED WITH SEMICONDUCTOR BARE CHIP AND METHOD OF THERMOCOMPRESSION-BONDING THE SAME GODO KAISHA IP BRIDGE 1 (JP) 2002-07-18 US disclosed
US-6042682-A Method of thermocompression bonding a supporting substrate to a semiconductor bare chip NEC CORPORATION (JP) 2000-03-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220153786-A1 PEPTIDES FOR PREVENTING BIOFILM FORMATION NGLY1, VIP, IDUA HCAR2 1783/4885HDAC3 3762/4885HDAC4 2493/4885
US-20160312385-A1 Nanofibers Containing Photocurable Ester Derivative of Hyaluronic Acid or Its Salt, Photocured Nanofibers, Method of Synthesis Thereof, Preparation Containing Photocured Nanofibers and Use Thereof CD44, SHH, MMP1 HCAR2 329/4885HDAC3 912/4885HDAC4 452/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.