Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL643619 | 0.86 | OPRM1 (0.51) | OPRM1OPRD1OPRK1OPRL1KCNA5 | |
| SCHEMBL12508473 | 0.85 | OPRM1 (0.45) | OPRM1OPRD1OPRK1OPRL1KCNA5 | |
| SCHEMBL493481 | 0.85 | OPRM1 (0.45) | OPRM1OPRD1OPRK1OPRL1KCNA5 | |
| SCHEMBL12508362 | 0.84 | OPRM1 (0.57) | OPRM1OPRD1OPRK1OPRL1KCNA5 | |
| SCHEMBL493273 | 0.82 | CACNA2D1 (0.57) | OPRM1OPRD1OPRK1OPRL1KCNA5 | |
| SCHEMBL645116 | 0.82 | OPRM1 (0.45) | OPRM1OPRD1OPRK1OPRL1KCNA5 | |
| SCHEMBL644155 | 0.81 | OPRM1 (0.42) | OPRM1OPRD1OPRK1OPRL1KCNA5 | |
| SCHEMBL493445 | 0.81 | OPRM1 (0.42) | OPRM1OPRD1OPRK1OPRL1KCNA5 | |
| SCHEMBL643851 | 0.81 | OPRM1 (0.44) | OPRM1OPRD1OPRK1OPRL1KCNA5 | |
| SCHEMBL644234 | 0.78 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119633-B2 | N-{2-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-2-oxo-ethoxy]-ethyl}-N-ethyl-4-methoxy-2,3,6-trimethyl-phenylsulfonamide; condensing the N-carboxyalkyl phenylsulfonamide with the substituted piperidine; bradykinin receptor antagonists; analgesics; antidiabetics; angiogenesis inhibitors; rheumatic diseases | GRUENENTHAL GMBH (DE) | 2012-02-21 | — | — | US | disclosed |