Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7796450 | 1.00 | KLK5 (0.47) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7283432 | 1.00 | KLK5 (0.47) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5142842 | 1.00 | KLK5 (0.47) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6305846 | 1.00 | KLK5 (0.47) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7398818 | 1.00 | KLK5 (0.47) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7635831 | 0.96 | KLK5 (0.44) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7635824 | 0.96 | KLK5 (0.44) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9546495 | 0.95 | KLK5 (0.43) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7636604 | 0.95 | CTSS (0.48) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9546501 | 0.95 | KLK5 (0.43) | KLK5PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6969731-B1 | Protease inhibitors that overcome drug resistance | The University of Illinois, Board of Trustees (US) | 2005-11-29 | — | — | US | disclosed |
| WO-1993019059-A1 | ANTIVIRAL PEPTIDES | PFIZER LIMITED (GB) | 1993-09-30 | — | — | WO | disclosed |