Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.91 |
| ▸ | PDE6C | P51160 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576608 | 0.95 | PDE5A (1.00) | PDE5APDE6C | |
| SCHEMBL6444754 | 0.94 | PDE5A (0.87) | PDE5APDE6C | |
| SCHEMBL3571036 | 0.93 | PDE5A (1.00) | PDE5APDE6C | |
| SCHEMBL6443212 | 0.93 | PDE5A (0.85) | PDE5APDE6C | |
| SCHEMBL3579733 | 0.93 | PDE5A (0.92) | PDE5APDE6C | |
| SCHEMBL13500475 | 0.92 | PDE5A (0.85) | PDE5APDE6C | |
| SCHEMBL3584023 | 0.92 | PDE5A (1.00) | PDE5APDE6C | |
| SCHEMBL6443570 | 0.92 | PDE5A (0.77) | PDE5APDE6C | |
| SCHEMBL3581025 | 0.91 | PDE5A (0.94) | PDE5APDE6C | |
| SCHEMBL6443630 | 0.91 | PDE5A (0.84) | PDE5APDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1371647-B1 | Pyridine-3-carboxylic acid derivatives and their use as intermediates | PFIZER (US) | 2005-07-13 | — | — | EP | disclosed |
| EP-1371647-A2 | Pyridine-3-carboxylic acid derivatives and their use as intermediates | PFIZER INC. (US) | 2003-12-17 | — | — | EP | disclosed |
| EP-1073658-B1 | PYRAZOLOPYRIMIDINONE CGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER (US) | 2003-08-13 | — | — | EP | disclosed |
| US-6458951-B2 | FOR TREATMENT OF MALE ERECTILE DYSFUNCTION, FEMALE SEXUAL DYSFUNCTION | PFIZER INC | 2002-10-01 | — | — | US | disclosed |
| US-6251904-B1 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-06-26 | — | — | US | disclosed |