Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTP4A3 | O75365 | 1/20 | 0.78 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.66 |
| ▸ | IGF1R | P08069 | 2/20 | 0.63 |
| ▸ | INSR | P06213 | 1/20 | 0.63 |
| ▸ | GSK3B | P49841 | 4/20 | 0.61 |
| ▸ | PIM1 | P11309 | 4/20 | 0.61 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.61 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.61 |
| ▸ | CDC7 | O00311 | 1/20 | 0.61 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.61 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.61 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.61 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.61 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.61 |
| ▸ | CLK2 | P49760 | 1/20 | 0.61 |
| ▸ | GSK3A | P49840 | 1/20 | 0.61 |
| ▸ | NEK4 | P51957 | 1/20 | 0.61 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.61 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6448803 | 1.00 | PTP4A3 (0.78) | PTP4A3CISD1IGF1RINSRGSK3B | |
| SCHEMBL6450013 | 1.00 | PTP4A3 (0.78) | PTP4A3CISD1IGF1RINSRGSK3B | |
| SCHEMBL8178908 | 0.88 | PTP4A3 (1.00) | PTP4A3CISD1GSK3BPIM1PIM2 | |
| SCHEMBL6413633 | 0.88 | PTP4A3 (0.73) | PTP4A3CISD1IGF1RINSRGSK3B | |
| SCHEMBL6413629 | 0.88 | PTP4A3 (0.73) | PTP4A3CISD1IGF1RINSRGSK3B | |
| SCHEMBL8178911 | 0.88 | PTP4A3 (1.00) | PTP4A3CISD1GSK3BPIM1PIM2 | |
| SCHEMBL8171933 | 0.84 | PTP4A3 (0.57) | PTP4A3CISD1IGF1RINSRGSK3B | |
| SCHEMBL1249438 | 0.83 | TDP1 (0.75) | CISD1IGF1RGSK3BPIM1PIM2 | |
| SCHEMBL1249440 | 0.83 | TDP1 (0.75) | CISD1IGF1RGSK3BPIM1PIM2 | |
| SCHEMBL12218285 | 0.83 | TDP1 (0.75) | CISD1IGF1RGSK3BPIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050020654-A1 | Novel PPAR agonists, pharmaceutical compositions and uses thereof | BETHESDA PHARMACEUTICALS, INC. | 2005-01-27 | — | — | US | disclosed |
| WO-2004082621-A2 | NOVEL PPAR AGONISTS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BETHESDA PHARMACEUTICALS, INC. (US) | 2004-09-30 | — | — | WO | disclosed |
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020654-A1 | Novel PPAR agonists, pharmaceutical compositions and uses thereof | PPARG, PPARD, PPARA | PTP4A3 1330/4885CISD1 2661/4885IGF1R 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.