Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 6/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 5/20 | 0.43 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.38 |
| ▸ | IL6ST | P40189 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL974301 | 1.00 | KLK7 (0.43) | KLK7KLK5PPARAPLA2G10PLA2G5 | |
| SCHEMBL6448978 | 1.00 | KLK7 (0.43) | KLK7KLK5PPARAPLA2G10PLA2G5 | |
| SCHEMBL2025733 | 1.00 | KLK7 (0.43) | KLK7KLK5PPARAPLA2G10PLA2G5 | |
| SCHEMBL7081418 | 0.94 | PPARA (0.46) | KLK7KLK5PPARAPLA2G10PLA2G5 | |
| SCHEMBL7081419 | 0.94 | PPARA (0.46) | KLK7KLK5PPARAPLA2G10PLA2G5 | |
| SCHEMBL7081422 | 0.94 | PPARA (0.46) | KLK7KLK5PPARAPLA2G10PLA2G5 | |
| SCHEMBL8828126 | 0.93 | PPARA (0.40) | KLK7KLK5PPARAPLA2G10PLA2G5 | |
| SCHEMBL8011986 | 0.92 | PPARA (0.39) | KLK7KLK5PPARAPLA2G10PLA2G5 | |
| SCHEMBL8554608 | 0.92 | FAAH (0.40) | KLK7KLK5PPARAPLA2G10PLA2G5 | |
| SCHEMBL17756172 | 0.92 | PPARA (0.39) | KLK7KLK5PPARAPLA2G10PLA2G5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-B1 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LAB (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| EP-0402646-A1 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-12-19 | — | — | EP | disclosed |