Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | FOS | P01100 | 1/20 | 0.38 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | GAPDH | P04406 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6449282 | 1.00 | CYP3A4 (0.55) | CYP3A4CYP2C9CYP2C19CA1KMT2A | |
| SCHEMBL866662 | 0.82 | MEN1 (0.49) | CYP3A4KMT2ARELAMAOBMEN1 | |
| SCHEMBL2522305 | 0.82 | MEN1 (0.49) | CYP3A4KMT2ARELAMAOBMEN1 | |
| SCHEMBL866661 | 0.82 | MEN1 (0.49) | CYP3A4KMT2ARELAMAOBMEN1 | |
| SCHEMBL11959996 | 0.82 | MEN1 (0.49) | CYP3A4KMT2ARELAMAOBMEN1 | |
| SCHEMBL11960056 | 0.82 | MEN1 (0.49) | CYP3A4KMT2ARELAMAOBMEN1 | |
| SCHEMBL16865352 | 0.78 | CYP2C9 (0.45) | CYP3A4CYP2C9CYP2C19CA1KMT2A | |
| SCHEMBL16865348 | 0.78 | CYP2C9 (0.45) | CYP3A4CYP2C9CYP2C19CA1KMT2A | |
| SCHEMBL12241652 | 0.77 | CYP3A4 (0.60) | CYP3A4CYP2C9CYP2C19CA1KMT2A | |
| SCHEMBL28847935 | 0.77 | CYP3A4 (0.60) | CYP3A4CYP2C9CYP2C19CA1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050038098-A1 | Substituted dihydronaphthalene and isochroman compounds for the treatment of metabolic disorders, cancer and other diseases | INCYTE CORPORATION | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038098-A1 | Substituted dihydronaphthalene and isochroman compounds for the treatment of metabolic disorders, cancer and other diseases | HSD17B10, IDH2, INSR | CYP3A4 187/4885CYP2C9 466/4885CYP2C19 526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.