Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 4/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | NAT1 | P18440 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 4/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6449303 | 1.00 | PTGS1 (0.47) | PTGS1PTGS2RAB9ANPC1HTT | |
| SCHEMBL6451356 | 0.85 | GSK3B (0.49) | PTGS1PTGS2RAB9ANPC1HTT | |
| SCHEMBL6451359 | 0.85 | GSK3B (0.49) | PTGS1PTGS2RAB9ANPC1HTT | |
| SCHEMBL6449258 | 0.85 | PIM1 (0.51) | PTGS1PTGS2RAB9ANPC1HTT | |
| SCHEMBL6449261 | 0.85 | PIM1 (0.51) | PTGS1PTGS2RAB9ANPC1HTT | |
| SCHEMBL6449159 | 0.81 | NPC1 (0.43) | PTGS1PTGS2RAB9ANPC1HTT | |
| SCHEMBL6449163 | 0.81 | NPC1 (0.43) | PTGS1PTGS2RAB9ANPC1HTT | |
| SCHEMBL6450520 | 0.78 | NPC1 (0.41) | PTGS1PTGS2RAB9ANPC1HTT | |
| SCHEMBL6450518 | 0.78 | NPC1 (0.41) | PTGS1PTGS2RAB9ANPC1HTT | |
| SCHEMBL6450595 | 0.78 | HPGD (0.48) | RAB9ANPC1HTTAKR1B1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014767-A1 | Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases | INCYTE CORPORATION | 2005-01-20 | — | — | US | disclosed |
| WO-2004066952-A2 | BENZOXAZOLE, BENZOTHIAZOLE, AND BENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT OF CANCER AND OTHER DISEASES | INCYTE CORPORATION (US) | 2004-08-12 | — | — | WO | disclosed |
| EP-1373216-A1 | 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY | Solvay Pharmaceuticals B.V. (NL) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002076949-A1 | 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY | SOLVAY PHARMACEUTICALS B.V. (NL) | 2002-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014767-A1 | Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases | AR, CCNT1, BRD1 | PTGS1 469/4885PTGS2 795/4885RAB9A 3637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.