Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.51 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.51 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 5/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | NEK4 | P51957 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6449261 | 1.00 | PIM1 (0.51) | PIM1PIM2PIM3PTGS1PTGS2 | |
| SCHEMBL6449306 | 0.85 | PTGS1 (0.47) | PIM1PIM2PIM3PTGS1PTGS2 | |
| SCHEMBL6449303 | 0.85 | PTGS1 (0.47) | PIM1PIM2PIM3PTGS1PTGS2 | |
| SCHEMBL6451359 | 0.82 | GSK3B (0.49) | PIM1PIM2PIM3PTGS1PTGS2 | |
| SCHEMBL6451356 | 0.82 | GSK3B (0.49) | PIM1PIM2PIM3PTGS1PTGS2 | |
| SCHEMBL6449159 | 0.80 | NPC1 (0.43) | PIM1PIM2PIM3PTGS1PTGS2 | |
| SCHEMBL6449163 | 0.80 | NPC1 (0.43) | PIM1PIM2PIM3PTGS1PTGS2 | |
| SCHEMBL6449142 | 0.79 | ALDH1A1 (0.40) | PTGS2RAB9ANPC1HPGDTDP1 | |
| SCHEMBL6450518 | 0.79 | NPC1 (0.41) | PIM1PIM2PIM3PTGS1PTGS2 | |
| SCHEMBL6450520 | 0.79 | NPC1 (0.41) | PIM1PIM2PIM3PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014767-A1 | Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases | INCYTE CORPORATION | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014767-A1 | Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases | AR, CCNT1, BRD1 | PIM1 1650/4885PIM2 1841/4885PIM3 2238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.