Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.40 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6446316 | 1.00 | LMNA (0.47) | LMNACYP3A4TBXAS1SLC1A5ABCB1 | |
| SCHEMBL9741503 | 1.00 | LMNA (0.47) | LMNACYP3A4TBXAS1SLC1A5ABCB1 | |
| SCHEMBL6448340 | 1.00 | LMNA (0.47) | LMNACYP3A4TBXAS1SLC1A5ABCB1 | |
| SCHEMBL7268965 | 0.99 | CYP3A4 (0.46) | LMNACYP3A4TBXAS1SLC1A5ABCB1 | |
| SCHEMBL9742860 | 0.96 | LMNA (0.44) | LMNACYP3A4TBXAS1SLC1A5ABCB1 | |
| SCHEMBL6447683 | 0.96 | LMNA (0.44) | LMNACYP3A4TBXAS1SLC1A5ABCB1 | |
| SCHEMBL9741196 | 0.90 | ABCB1 (0.43) | LMNACYP3A4ABCB1SLC15A1CTSB | |
| SCHEMBL6454316 | 0.90 | ABCB1 (0.43) | LMNACYP3A4ABCB1SLC15A1CTSB | |
| SCHEMBL6448984 | 0.90 | ABCB1 (0.43) | LMNACYP3A4ABCB1SLC15A1CTSB | |
| SCHEMBL7268569 | 0.89 | ABCB1 (0.44) | LMNACYP3A4ABCB1SLC15A1CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0402646-A1 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-12-19 | — | — | EP | claimed |
| EP-0839798-B1 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LAB (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-0402646-B1 | Retroviral protease inhibiting compounds | ABBOTT LAB (US) | 1998-07-22 | — | — | EP | disclosed |
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| EP-0402646-A1 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-12-19 | — | — | EP | disclosed |