⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23748409 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL23748410 | 0.86 | — | — | |
| SCHEMBL27197468 | 0.80 | — | — | |
| SCHEMBL34471285 | 0.78 | — | — | |
| SCHEMBL18902192 | 0.74 | TRIM24 (0.35) | — | |
| SCHEMBL16336091 | 0.74 | TRIM24 (0.31) | — | |
| SCHEMBL30690314 | 0.74 | TRIM24 (0.36) | — | |
| SCHEMBL23124090 | 0.73 | — | — | |
| SCHEMBL26101713 | 0.73 | TRIM24 (0.33) | — | |
| Ethylene SCHEMBL3464024 | 0.71 | TRIM24 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0447345-A2 | New Azaspyro [4.5] decane-7,9-dione derivatives | FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A. (FAES) (ES) | 1991-09-18 | — | — | EP | claimed |
| EP-0395192-A2 | Process for the preparation of 8-(4-(4-pyrimidin-2-yl-piperazinyl)-butyl)-8-aza-spiro(4.5)decane-7,9-dione (buspiron) | ALKALOIDA VEGYESZETI GYAR (HU) | 1990-10-31 | — | — | EP | claimed |
| JP-8092221-A | — | — | None | — | — | JP | disclosed |
| US-20050080084-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of central nervous system damage | PHARMACIA CORPORATION | 2005-04-14 | — | — | US | disclosed |
| JP-H0892221-A | NEW AZASPIRO(4,5)DECANE-7,9-DIONE DERIVATIVE | FAB ESPANOLA DE PROD QUIMICOS I FARMACEUT SA | 1996-04-09 | — | — | JP | disclosed |
| EP-0447345-A2 | New Azaspyro [4.5] decane-7,9-dione derivatives | FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A. (FAES) (ES) | 1991-09-18 | — | — | EP | disclosed |
| EP-0395192-A2 | Process for the preparation of 8-(4-(4-pyrimidin-2-yl-piperazinyl)-butyl)-8-aza-spiro(4.5)decane-7,9-dione (buspiron) | ALKALOIDA VEGYESZETI GYAR (HU) | 1990-10-31 | — | — | EP | disclosed |