Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 3/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.53 |
| ▸ | ECE1 | P42892 | 4/20 | 0.52 |
| ▸ | MME | P08473 | 3/20 | 0.52 |
| ▸ | CTSD | P07339 | 2/20 | 0.52 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.49 |
| ▸ | IL1RN | P18510 | 1/20 | 0.49 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.49 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8536011 | 0.97 | CTSB (0.53) | CTSBCTSKECE1MMECTSD | |
| SCHEMBL8535165 | 0.85 | CTSB (0.56) | CTSBCTSKECE1MMECTSD | |
| SCHEMBL23051873 | 0.84 | CTSB (0.59) | CTSBCTSKECE1MMEERAP2 | |
| SCHEMBL12516497 | 0.81 | ERAP2 (0.57) | CTSBCTSKERAP2IL1RNERAP1 | |
| SCHEMBL31410669 | 0.80 | CTSB (0.56) | CTSBCTSKECE1ERAP2IL1RN | |
| SCHEMBL21274440 | 0.79 | ERAP2 (0.56) | CTSBCTSKERAP2IL1RNERAP1 | |
| SCHEMBL21274443 | 0.79 | ERAP2 (0.56) | CTSBCTSKERAP2IL1RNERAP1 | |
| SCHEMBL29770313 | 0.79 | ERAP2 (0.68) | CTSBCTSKCTSDERAP2IL1RN | |
| Hydrochloric Acid SCHEMBL6283276 | 0.79 | CTSB (0.55) | CTSBCTSKECE1ERAP2IL1RN | |
| SCHEMBL9411663 | 0.79 | KLK5 (0.52) | CTSBCTSKECE1MMECTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-B1 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LAB (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-0402646-B1 | Retroviral protease inhibiting compounds | ABBOTT LAB (US) | 1998-07-22 | — | — | EP | disclosed |
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| US-5142056-A | Human immunodeficiency virus protease inhibitor | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | disclosed |