Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.97 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.78 |
| ▸ | AKR1C2 | P52895 | 9/20 | 0.78 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.78 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.78 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.78 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.78 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.78 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.78 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.78 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.78 |
| ▸ | FABP2 | P12104 | 1/20 | 0.78 |
| ▸ | TSHR | P16473 | 1/20 | 0.78 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.78 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4'-Hydroxyflurbiprofen SCHEMBL7040151 | 1.00 | APP (0.97) | APPCYP2C19CYP2C9CYP3A4AKR1C3 | |
| SCHEMBL2778899 | 0.98 | APP (1.00) | APPCYP2C19CYP2C9CYP3A4AKR1C3 | |
| SCHEMBL17524312 | 0.91 | APP (0.81) | APPCYP2C19CYP2C9CYP3A4AKR1C3 | |
| SCHEMBL1679257 | 0.91 | APP (0.81) | APPCYP2C19CYP2C9CYP3A4AKR1C3 | |
| SCHEMBL9667811 | 0.89 | AKR1C3 (0.80) | APPCYP2C19CYP2C9CYP3A4AKR1C3 | |
| Flurbiprofen SCHEMBL10029029 | 0.88 | AKR1C3 (1.00) | APPCYP2C19CYP2C9CYP3A4AKR1C3 | |
| Flurbiprofen SCHEMBL8755275 | 0.88 | AKR1C3 (1.00) | APPCYP2C19CYP2C9CYP3A4AKR1C3 | |
| Esflurbiprofen SCHEMBL505817 | 0.88 | AKR1C3 (1.00) | APPCYP2C19CYP2C9CYP3A4AKR1C3 | |
| Flurbiprofen SCHEMBL8754978 | 0.88 | AKR1C3 (1.00) | APPCYP2C19CYP2C9CYP3A4AKR1C3 | |
| Tarenflurbil SCHEMBL26131 | 0.88 | AKR1C3 (1.00) | APPCYP2C19CYP2C9CYP3A4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119541903-B | Method for identifying effectiveness of gastrodia elata extract in preventing and treating parkinsonism | 中国农业科学院农产品加工研究所 | 2025-06-13 | — | — | CN | claimed |
| CN-119541903-A | Method for identifying effectiveness of gastrodia elata extract in preventing and treating parkinsonism | 中国农业科学院农产品加工研究所 | 2025-02-28 | — | — | CN | claimed |
| CN-119541903-B | Method for identifying effectiveness of gastrodia elata extract in preventing and treating parkinsonism | 中国农业科学院农产品加工研究所 | 2025-06-13 | — | — | CN | disclosed |
| CN-119541903-A | Method for identifying effectiveness of gastrodia elata extract in preventing and treating parkinsonism | 中国农业科学院农产品加工研究所 | 2025-02-28 | — | — | CN | disclosed |
| CN-116924910-A | Impurity removing method for flurbiprofen axetil | 南京优科生物医药股份有限公司 | 2023-10-24 | — | — | CN | disclosed |
| CN-114814026-A | Impurity detection method of flurbiprofen axetil | 南京优科生物医药股份有限公司 | 2022-07-29 | — | — | CN | disclosed |
| US-20160038448-A1 | THE INHIBITION OF THE TOXIC EFFECTS OF ISLET AMYLOID FORMATION BY FLURBIPROFEN AND FLURBIPROFEN DERIVATIVES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2016-02-11 | — | — | US | disclosed |
| US-20160038448-A1 | THE INHIBITION OF THE TOXIC EFFECTS OF ISLET AMYLOID FORMATION BY FLURBIPROFEN AND FLURBIPROFEN DERIVATIVES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2016-02-11 | — | — | US | disclosed |
| WO-2014159772-A2 | INHIBITION OF THE TOXIC EFFECTS OF ISLET AMYLOID FORMATION BY FLURIPROFEN AND FLURIPROFEN DERIVATIVES | THE RESEARCH FOUNDATION FOR THE STATW UNIVERSITY OF NEW YORK (US) | 2014-10-02 | — | — | WO | disclosed |
| US-20050288375-A1 | Method and composition for treating neurodegenerative disorders | MYRIAD GENETICS, INCORPORATED (US) | 2005-12-29 | — | — | US | disclosed |
| WO-2003003012-A1 | IDENTIFICATION OF INTERACTING MOLECULES | MEDIMOLECULAR PTY. LTD. (AU) | 2003-01-09 | — | — | WO | disclosed |
| US-6100260-A | ((3-(1-(2-FLUORO-BIPHENYL-4-YL)-ETHYL)-ISOXAZOL-5-YLIMINO) -MORPHOLIN-4-YL-M ETHYL)-AMINE, FOR EXAMPLE; ADMINISTERING TO TREAT AUTOIMMUNE DISEASES AND INFLAMMATION | SUMITOMO PHARMACEUTICAL COMPANY, LIMITED (JP) | 2000-08-08 | — | — | US | disclosed |
| US-4008208-A | Compositions having inhibited ability to promote platelet aggregation or fibrin clot formation | THE UPJOHN COMPANY (US) | 1977-02-15 | — | — | US | disclosed |
| US-3975371-A | Aromatic azo sulfonylnitrene compounds | THE UPJOHN COMPANY (US) | 1976-08-17 | — | — | US | disclosed |
| US-3954583-A | Photochemical process | THE UPJOHN COMPANY (US) | 1976-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160038448-A1 | THE INHIBITION OF THE TOXIC EFFECTS OF ISLET AMYLOID FORMATION BY FLURBIPROFEN AND FLURBIPROFEN DERIVATIVES | IAPP, AMY2A, APP | APP 3/4885CYP2C19 858/4885CYP2C9 645/4885 |
| US-20050288375-A1 | Method and composition for treating neurodegenerative disorders | GRIN2A, GRIN2B, GRIN3A | APP 8/4885CYP2C19 76/4885CYP2C9 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.