Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 7/20 | 0.60 |
| ▸ | MMP13 | P45452 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | ULK1 | O75385 | 5/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MARK3 | P27448 | 1/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6450864 | 0.83 | MMP12 (0.62) | MMP12MMP13ABL1ULK1MMP2 | |
| SCHEMBL6450492 | 0.83 | MMP12 (0.60) | MMP12MMP13ABL1ULK1MMP2 | |
| SCHEMBL6451092 | 0.83 | MMP12 (0.59) | MMP12MMP13ABL1ULK1CFTR | |
| SCHEMBL6468492 | 0.83 | MMP12 (0.63) | MMP12MMP13ABL1IKBKETBK1 | |
| SCHEMBL6881919 | 0.81 | MMP12 (0.58) | MMP12MMP13ABL1ULK1IKBKE | |
| SCHEMBL6885130 | 0.81 | MMP12 (0.58) | MMP12MMP13ABL1ULK1IKBKE | |
| SCHEMBL6462719 | 0.81 | MMP12 (0.64) | MMP12MMP13ABL1MAPK1EPHX2 | |
| SCHEMBL6463535 | 0.81 | MMP12 (0.88) | MMP12MMP13ABL1MMP2MMP8 | |
| SCHEMBL6450644 | 0.80 | MMP12 (0.56) | MMP12MMP13ABL1ULK1IKBKE | |
| SCHEMBL6451716 | 0.79 | MMP12 (0.81) | MMP12MMP13ABL1MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534700-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004018448-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2004-03-04 | — | — | WO | disclosed |