SCHEMBL6452850

SCHEMBL6452850

Cc1ccc(O)c(Cc2cc(C(C)(C)C)cc(C(C)(C)C)c2O)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSPA5 P11021 2/20 0.61
AMY1A P0DUB6 1/20 0.61
CYP2C19 P33261 6/20 0.59
CYP2C9 P11712 4/20 0.59
HIF1A Q16665 3/20 0.59
SMN1; SMN2 Q16637 3/20 0.59
CYP2D6 P10635 4/20 0.54
HSD17B10 Q99714 2/20 0.54
ALDH1A1 P00352 3/20 0.41
CA2 P00918 1/20 0.41
POLB P06746 1/20 0.41
TYR P14679 1/20 0.41
MAPK1 P28482 2/20 0.40
GAA P10253 1/20 0.40
XBP1 P17861 1/20 0.40
HTT P42858 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
CYP3A4 P08684 2/20 0.40
CYP1A2 P05177 2/20 0.40
TSHR P16473 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL722580 0.89 HSPA5 (0.77) HSPA5AMY1ACYP2C19CYP2C9HIF1A
SCHEMBL22500379 0.88 AMY1A (0.65) HSPA5AMY1ACYP2C19CYP2C9HIF1A
SCHEMBL31281158 0.86 HSPA5 (0.83) HSPA5AMY1ACYP2C19CYP2C9HIF1A
SCHEMBL8055757 0.86 CYP2C19 (0.80) HSPA5AMY1ACYP2C19CYP2C9HIF1A
SCHEMBL28074255 0.85 AMY1A (0.66) HSPA5AMY1ACYP2C19CYP2C9HIF1A
SCHEMBL30578945 0.84 AMY1A (0.62) HSPA5AMY1ACYP2C19CYP2C9HIF1A
SCHEMBL39554 0.84 HSPA5 (0.66) HSPA5CYP2C19CYP2C9HIF1ASMN1; SMN2
SCHEMBL30903568 0.84 HSPA5 (0.66) HSPA5CYP2C19CYP2C9HIF1ASMN1; SMN2
SCHEMBL29500375 0.84 HSPA5 (0.66) HSPA5CYP2C19CYP2C9HIF1ASMN1; SMN2
SCHEMBL2786708 0.82 CYP2C19 (0.67) HSPA5CYP2C19CYP2C9HIF1ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005082531-A1 TRANSITION METAL COMPLEXES AND THEIR USES AS CATALYSTS UEA ENTERPRISES LTD (GB) 2005-09-09 WO claimed
WO-2005082531-A1 TRANSITION METAL COMPLEXES AND THEIR USES AS CATALYSTS UEA ENTERPRISES LTD (GB) 2005-09-09 WO disclosed