Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.84 |
| ▸ | PDE4D | Q08499 | 17/20 | 0.84 |
| ▸ | PDE4A | P27815 | 16/20 | 0.84 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.84 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6453687 | 1.00 | PDE4B (0.84) | PDE4BPDE4DPDE4APDE4CPDE7A | |
| Hydrochloric Acid SCHEMBL4015397 | 0.99 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4CPDE7A | |
| Hydrochloric Acid SCHEMBL4015390 | 0.99 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4CPDE7A | |
| Hydrochloric Acid SCHEMBL4015395 | 0.99 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4CPDE7A | |
| SCHEMBL6876779 | 0.91 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4CPDE7A | |
| SCHEMBL6876771 | 0.91 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4CPDE7A | |
| SCHEMBL6876774 | 0.91 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4CPDE7A | |
| Hydrochloric Acid SCHEMBL6470670 | 0.90 | PDE4B (0.68) | PDE4BPDE4DPDE4APDE4CPDE7A | |
| Hydrochloric Acid SCHEMBL6470669 | 0.90 | PDE4B (0.68) | PDE4BPDE4DPDE4APDE4CPDE7A | |
| SCHEMBL5557664 | 0.90 | PDE4B (0.84) | PDE4BPDE4DPDE4APDE4CPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537100-A1 | PYRROLIDINEDIONE SUBSTITUTED PIPERIDINE-PHTHALAZONES AS PDE4 INHIBITORS | ALTANA Pharma AG (DE) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004018457-A1 | PYRROLIDINEDIONE SUBSTITUTED PIPERIDINE-PHTHALAZONES AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2004-03-04 | — | — | WO | disclosed |