Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.51 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CTSV | O60911 | 2/20 | 0.50 |
| ▸ | CTSL | P07711 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7048751 | 0.88 | SMPD1 (0.53) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL6458759 | 0.86 | MAOB (0.58) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL6620047 | 0.85 | HTT (0.64) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL15080744 | 0.85 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL4469125 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL12082074 | 0.84 | SMPD1 (0.54) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL340527 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL31564771 | 0.84 | SMPD1 (0.54) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL30302025 | 0.84 | SMPD1 (0.54) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL13070163 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1HPGDRAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888310-B1 | CINNOLINE DERIVATIVES AND USE AS MEDICINE | ASTRAZENECA AB (SE) | 2005-09-07 | — | — | EP | disclosed |